Document Detail

Melatonin Does Not Affect Oxidative/Inflammatory Biomarkers in a Closed-Chest Porcine Model of Acute Myocardial Infarction.
MedLine Citation:
PMID:  24982213     Owner:  NLM     Status:  Publisher    
Aim: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. Materials and Methods: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion. Results: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups. Conclusion: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.
Natalie L Halladin; Sarah Ekeløf; Svend Eggert Jensen; Jens Aarøe; Benedict Kjærgaard; Peter M H Heegaard; Jens Lykkesfeldt; Jacob Rosenberg; Ismail Gögenur
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Publication Detail:
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  28     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:    2014 07-08
Date Detail:
Created Date:  2014-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  -    
Other Details:
Languages:  ENG     Pagination:  483-488     Citation Subset:  -    
Copyright Information:
Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
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