Document Detail

Melanotropic drugs and retinal functions. II. Effects of phenothiazine and rifampicin on the sheep ERG.
MedLine Citation:
PMID:  946357     Owner:  NLM     Status:  MEDLINE    
The acute effects of chlorpromazine, promethazine and rifampicin on the a-, b- and c-waves of the conventional electroretinogram (ERG) were studied in sheep. Iv administration of chlorpromazine and promethazine resulted in a b-wave amplitude decrease and an initial c-wave amplitude decrease, followed by cyclic amplitude changes resembling damped oscillations. Iv injections of rifampicin, however, resulted in cyclic changes of the c-wave amplitude without initial concomitant b-wave changes. The results of the present study indicate that rifampicin has a selective influence on the pigment epithelial cells, while chlorpromazine and promethazine seem to have more generalized retinal effects on both the neuroretina and the pigment epithelial cells.
B Calissendorff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  54     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-15     Completed Date:  1976-04-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  118-28     Citation Subset:  IM    
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MeSH Terms
Chlorpromazine / pharmacology*
Pigment Epithelium of Eye / cytology,  drug effects*
Promethazine / pharmacology*
Retina / drug effects*,  physiology
Rifampin / pharmacology*
Reg. No./Substance:
13292-46-1/Rifampin; 50-53-3/Chlorpromazine; 60-87-7/Promethazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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