Document Detail

Melanotropic drugs and retinal functions. I. Effects of quinine and chloroquine on the sheep ERG.
MedLine Citation:
PMID:  946356     Owner:  NLM     Status:  MEDLINE    
The present work is the first in a series of investigations on the effects of melanotropic drugs on retinal function. Teh changes in the conventional ERG of the dark-adapted, intact sheep eye were studied after iv administrations of quinine and chloroquine. Both drugs influenced the ERG in principally the same way. Small doses changed only the c-wave amplitude which began to oscillate after a delay of about 1 hour. Larger doses had an immediate effect on both the b- and c-waves. The b-wave amplitude dropped and the c-wave showed an initial peak followed by oscillatory changes about 1 h later. These late changes were similar to those observed after administration of small doses of the drugs. The present results indicate that small doses of quinine and chlorquine have a delayed effect on the pigment epithelial cells, while larger doses exert a more immediate and general retinotoxic effect.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  54     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-15     Completed Date:  1976-04-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  109-17     Citation Subset:  IM    
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MeSH Terms
Chloroquine / administration & dosage,  pharmacology*
Pigment Epithelium of Eye / cytology,  drug effects*
Quinine / administration & dosage,  pharmacology*
Retina / drug effects*,  physiology
Reg. No./Substance:
130-95-0/Quinine; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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