Document Detail

Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases.
MedLine Citation:
PMID:  19669690     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Melanotic neuroectodermal tumor of infancy (MNT1) is a rare congenital pigmented neoplasm of neural crest origin, locally aggressive, and rapidly growing that develops during the first year of life. It most commonly arises from the maxilla, the cranial vault, and the mandible. Early diagnosis and radical surgery are critical for a long-term outcome. METHODS: A literature search through PUBMED revealed 43 cases of MNT1 arising in the skull. We reviewed the available literature and studied the presenting symptoms, diagnostic procedures, treatment, rates of recurrences, malignancy, and data of follow-up. We report two further cases of infants aged 4 and 10 months, respectively, with MNT1 arising from the cranial vault who underwent radical excision of the lesion. CONCLUSION: Melanotic neuroectodermal tumor of infancy should be included in the differential diagnosis of skull lesions in infants. Radical surgery must be considered as the treatment of choice and close follow-up for at least 2 years is necessary.
Vassilis Lambropoulos; Andreas Neofytou; Dimitris Sfougaris; Vassilis Mouravas; Anastasios Petropoulos
Publication Detail:
Type:  Case Reports; Journal Article; Randomized Controlled Trial; Review     Date:  2009-08-11
Journal Detail:
Title:  Acta neurochirurgica     Volume:  152     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  869-75     Citation Subset:  IM    
Department of Pediatric Surgery, Aristotle University, G.H. Papageorgiou, Ring Road N. Efkarpia, Thessaloniki, Greece.
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MeSH Terms
Combined Modality Therapy / methods,  standards
Diagnosis, Differential
Head and Neck Neoplasms / pathology*,  physiopathology,  surgery
Immunohistochemistry / methods
Neoplasm Invasiveness / pathology,  physiopathology,  prevention & control
Neoplasm Recurrence, Local / prevention & control
Neuroectodermal Tumor, Melanotic / pathology*,  physiopathology,  surgery
Neurosurgical Procedures / methods
Radiotherapy / methods,  standards
Skull / pathology*,  physiopathology,  surgery
Skull Neoplasms / pathology*,  physiopathology,  surgery
Stem Cells / metabolism,  pathology
Tumor Markers, Biological / analysis,  metabolism
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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