| Melanopsin and inner retinal photoreception. | |
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MedLine Citation:
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PMID: 19865798 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Over the last ten years there has been growing acceptance that retinal photoreception among mammals extends beyond rods and cones to include a small number of intrinsically photosensitive retinal ganglion cells (ipRGCs). These ipRGCs are capable of responding to light in the absence of rod/cone input thanks to expression of an opsin photopigment called melanopsin. They are specialised for measuring ambient levels of light (irradiance) for a wide variety of so-called non-image-forming light responses. These include synchronisation of circadian clocks to light:dark cycles and the regulation of pupil size, sleep propensity and pineal melatonin production. Here, we provide a review of some of the landmark discoveries in this fast developing field, paying particular emphasis to recent findings and key areas for future investigation. |
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Authors:
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Helena J Bailes; Robert J Lucas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-29 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 67 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 99-111 Citation Subset: IM |
Affiliation:
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Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK. helena.bailes@manchester.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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