Document Detail

Melanonychia induced by topical treatment of periungual warts with 5-fluorouracil.
MedLine Citation:
PMID:  23552007     Owner:  NLM     Status:  In-Data-Review    
Periungal and subungual warts are benign epidermal neoplasms caused by human papillomaviruses. They represent a challenge for management because of resistance to treatment. 5-flourouracil is an antimetabolite that interferes with DNA synthesis and inhibits RNA formation. We present a 32-year-old female with subungual and periungual warts of the fingers of both hands and first right toe. She was treated with 5-fluorouracil twice daily under occlusion plus 20 percent urea. After a month she presented with grayish transverse melanonychia along and parallel to the lunula with some maceration of the periungal folds. Nail pigmentation may be a consequence of dermal deposition by systemic drugs and less frequently by topical drugs. In this case melanonychia was induced by the topical application of 5-fluorouracil. The brown-grayish pigmentation, with parallel involvement of the lunula of all the nails treated, presented like that induced by systemically administered cytotoxic drugs.
Mariana Catalina De Anda; Judith Guadalupe Domínguez
Related Documents :
17724767 - In vitro activity of an essential oil against leishmania donovani.
8849257 - Microtubule inhibitors: structure-activity analyses suggest rational models to identify...
24591827 - Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced c...
15615527 - "lead hopping". validation of topomer similarity as a superior predictor of similar bio...
11002907 - The tonic/phasic model of dopamine system regulation and its implications for understan...
711867 - The sex role identity of male drug abusers.
Publication Detail:
Type:  Journal Article     Date:  2013-03-15
Journal Detail:
Title:  Dermatology online journal     Volume:  19     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10     Citation Subset:  IM    
Department of Dermatology, Hospital "Dr. Manuel Gea González," Mexico City, Mexico.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Unknown: Congenital linear whitish papules in a 3-year-old boy.
Next Document:  Non-healing verrucous plaque over upper limb for 1 year in a tea garden worker.