| Melanoma with second myxoid stromal changes after personally applied prolonged phototherapy. | |
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MedLine Citation:
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PMID: 18360128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most malignant melanomas are easily diagnosed; however, melanoma is also one of the lesions most frequently reported to mimic other tumors. One of the most difficult patterns to recognize is characterized by prominent myxoid matrix. A case is presented of primary cutaneous melanoma with abundant myxoid matrix in a patient who underwent prolonged phototherapy. Three years before, after getting sunburns, the patient noticed changes of a congenital nevus located in the area of sunburns. It became darker, started to blanch, and grew, with occasional bleeding. Without consulting a physician, the patient applied phototherapy onto the area for 30 months. He used a Bioptron lamp with polarized, polychromatic, incoherent light, at a wavelength from 480 to 3400 nm, without ultraviolet radiation. Clinically, the lesion was unevenly pigmented, ulcerated, covered with hemorrhagic crust, and measuring 3.5 cm in greatest dimension, with a satellite nodule. Multiple metastatic subcutaneous nodules were also found on the scalp and trunk. Histologically, the primary tumor and metastases were composed of nests and pseudotubular formations of polygonal, spindle, and stellate cells embedded in abundant myxoid stroma that comprised more than 80% of the tumor mass. Focally, in the epidermis and papillary dermis, nests of atypical melanocytes and numerous melanophages were observed. Chemotherapy and immunotherapy were administered as suggested by an oncologist. The patient died from distant metastases 6 months after the diagnosis. Although some authors believe that myxoid changes do not seem to alter the behavior of melanoma, it remains an important differential diagnosis issue. |
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Authors:
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Monika Ulamec; Antica Soldo-Belić; Majda Vucić; Marija Buljan; Bozo Kruslin; Davor Tomas |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 30 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-24 Completed Date: 2008-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 185-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, Ljudevit Jurak, Sestre Milosrdnice University Hospital, Zagreb, Croatia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy, Needle Cell Transformation, Neoplastic / pathology* Follow-Up Studies Humans Immunohistochemistry Lymph Nodes / pathology* Lymphatic Metastasis Male Melanoma / pathology, secondary*, therapy Neoplasm Staging Phototherapy / adverse effects, methods* Risk Assessment Skin Neoplasms / pathology*, physiopathology, therapy Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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