Document Detail

Melanoma revives an embryonic migration program to promote plasticity and invasion.
MedLine Citation:
PMID:  22681858     Owner:  NLM     Status:  MEDLINE    
Cancer cells must regulate plasticity and invasion to survive and metastasize. However, the identification of targetable mechanisms to inhibit metastasis has been slow. Signaling programs that drive stem and progenitor cells during normal development offer an inroad to discover mechanisms common to metastasis. Using a chick embryo transplant model, we have compared molecular signaling programs of melanoma and their embryonic progenitors, the neural crest. We report that malignant melanoma cells hijack portions of the embryonic neural crest invasion program. Genes associated with neural crest induction, delamination, and migration are dynamically regulated by melanoma cells exposed to an embryonic neural crest microenvironment. Specifically, we demonstrate that metastatic melanoma cells exploit neural crest-related receptor tyrosine kinases to increase plasticity and facilitate invasion while primary melanocytes may actively suppress these responses under the same microenvironmental conditions. We conclude that aberrant regulation of neural crest developmental genes promotes plasticity and invasiveness in malignant melanoma.
Caleb M Bailey; Jason A Morrison; Paul M Kulesa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-02
Journal Detail:
Title:  Pigment cell & melanoma research     Volume:  25     ISSN:  1755-148X     ISO Abbreviation:  Pigment Cell Melanoma Res     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-03     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101318927     Medline TA:  Pigment Cell Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-83     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Stowers Institute for Medical Research, Kansas City, MO, USA.
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MeSH Terms
Cell Differentiation
Cell Line, Tumor
Cell Movement*
Cellular Microenvironment / genetics
Chick Embryo
Disease Progression
Ephrins / genetics,  metabolism
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Melanocytes / pathology
Melanoma / pathology*
Neoplasm Invasiveness
Neoplasm Transplantation
Neural Crest / embryology*,  metabolism,  pathology*
Receptors, Eph Family / genetics,  metabolism
Signal Transduction / genetics
Grant Support
5F32CA144297/CA/NCI NIH HHS; F32 CA144297/CA/NCI NIH HHS
Reg. No./Substance:
0/Ephrins; EC, Eph Family

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