| Melanoma revives an embryonic migration program to promote plasticity and invasion. | |
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MedLine Citation:
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PMID: 22681858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancer cells must regulate plasticity and invasion to survive and metastasize. However, the identification of targetable mechanisms to inhibit metastasis has been slow. Signaling programs that drive stem and progenitor cells during normal development offer an inroad to discover mechanisms common to metastasis. Using a chick embryo transplant model, we have compared molecular signaling programs of melanoma and their embryonic progenitors, the neural crest. We report that malignant melanoma cells hijack portions of the embryonic neural crest invasion program. Genes associated with neural crest induction, delamination, and migration are dynamically regulated by melanoma cells exposed to an embryonic neural crest microenvironment. Specifically, we demonstrate that metastatic melanoma cells exploit neural crest-related receptor tyrosine kinases to increase plasticity and facilitate invasion while primary melanocytes may actively suppress these responses under the same microenvironmental conditions. We conclude that aberrant regulation of neural crest developmental genes promotes plasticity and invasiveness in malignant melanoma. |
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Authors:
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Caleb M Bailey; Jason A Morrison; Paul M Kulesa |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-08-02 |
Journal Detail:
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Title: Pigment cell & melanoma research Volume: 25 ISSN: 1755-148X ISO Abbreviation: Pigment Cell Melanoma Res Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-28 Completed Date: 2013-01-03 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: England |
Other Details:
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Languages: eng Pagination: 573-83 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Stowers Institute for Medical Research, Kansas City, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Line, Tumor Cell Movement* Cellular Microenvironment / genetics Chick Embryo Disease Progression Ephrins / genetics, metabolism Gene Expression Profiling Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Humans Melanocytes / pathology Melanoma / pathology* Neoplasm Invasiveness Neoplasm Transplantation Neural Crest / embryology*, metabolism, pathology* Receptors, Eph Family / genetics, metabolism Signal Transduction / genetics |
| Grant Support | |
ID/Acronym/Agency:
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5F32CA144297/CA/NCI NIH HHS; F32 CA144297/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ephrins; EC 2.7.10.1/Receptors, Eph Family |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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