| Melanogenesis Inhibitory Activity of Sesquiterpenes from Canarium ovatum Resin in Mouse B16 Melanoma Cells. | |
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MedLine Citation:
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PMID: 22899610 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Four known sesquiterpene alcohols, i.e., 1-4, ten triterpene alcohols, i.e., 5-14, and four triterpene acids, i.e., 15-18, were isolated from the MeOH extract of Canarium ovatum resin (elemi resin). Upon evaluation of the previously described compounds 1-18 on the melanogenesis in B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), three sesquiterpene alcohols, i.e., cryptomeridiol (1), 4-epicryptomeridiol (2), and cadin-1(14)-ene-7α,11-diol (4), exhibited inhibitory effects with 27.4-34.1 and 39.0-56.9% reduction of melanin content at 50 and 100 μM, respectively, with no or very low toxicity to the cells (80.9-103.9% of cell viability at 100 μM). Western-blot analysis revealed that compounds 1 and 2 reduced the protein levels of MITF (=microphtalmia-associated transcription factor), tyrosinase, and TRP-2 (=tyrosine-related protein 2), mostly in a concentration-dependent manner, suggesting that these compounds exhibit melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase and TRP-2. Three sesquiterpene alcohols, i.e., 1, 2, and 4, are, therefore, considered to be valuable as potential skin-whitening agents. |
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Authors:
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Takashi Kikuchi; Kensuke Watanabe; Yuichi Tochigi; Ayako Yamamoto; Makoto Fukatsu; Yoichiro Ezaki; Reiko Tanaka; Toshihiro Akihisa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 9 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1500-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich. |
Affiliation:
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College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan (fax: +81-3-32937572); Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. |
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