Document Detail


Melanocytic Matricoma With Melanocytic Atypia: Report of a Unique Case and Review of the Literature.
MedLine Citation:
PMID:  21252635     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Melanocytic matricoma is a rare cutaneous neoplasm of presumed anagen hair follicle origin with approximately 10 reported cases in the literature. Melanocytic matricomas are clinically and histopathologically distinct cutaneous nodular proliferations of matrical and supramatrical cells admixed with dendritic melanocytes, which typically occur in the sun-exposed areas of elderly patients. We report a new case with additional histopathologic features not previously described. An 82-year-old white man presented with an exophytic papule of the ear clinically suspicious for basal cell carcinoma. Histopathologic examination demonstrated a polypoid neoplasm consisting of an admixture of matrical and shadow cells with numerous interspersed dendritic and epithelioid melanocytes arranged singly and in large expansile nests. An unusual feature in this case included prominent melanocytic proliferation with associated nuclear atypia and increased mitotic activity. Although atypical and malignant melanocytic colonization has been reported in basal cell carcinomas and squamoproliferative lesions, to our knowledge, it has not been previously described in melanocytic matricomas. The biologic significance of atypical melanocytic proliferations within melanocytic matricomas is uncertain and requires further study of additional cases and long-term follow-up.
Authors:
Jamie Zussman; Sachiv Sheth; Seong H Ra; Scott W Binder
Related Documents :
17145625 - Stability of leukemia-associated immunophenotypes in precursor b-lymphoblastic leukemia...
11381435 - Surgical implications of pseudomonas aeruginosa necrotizing fasciitis in a child with a...
19785025 - Chronic idiopathic myelofibrosis with myeloid metaplasia presenting as refractory ascites.
1477645 - Acute leukemias with the t(4;11)(q21;q23).
25364465 - Giant cell tumor of the clivus: a case report and review of the literature.
10928675 - Intramuscular lipoma of the eyelid.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-19
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  -     ISSN:  1533-0311     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the *Department of Medicine, Division of Dermatology; and †Department of Pathology and Laboratory Medicine, Division of Dermatopathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles CA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antiretroviral therapy and sexual behavior in Uganda: a cohort study.
Next Document:  Eccrine Syringofibroadenoma and Clear Cell Acanthoma: An Association by Chance?