| Melanocyte-stimulating activity in fetal, newborn and adult guinea-pigs: studies of the pituitary, blood plasma and amniotic fluid. | |
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MedLine Citation:
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PMID: 7142674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melanocyte-stimulating activity in the pituitary and plasma of fetal, newborn and adult guinea-pigs, and in amniotic fluid, was bioassayed on isolated Anolis skin. In the fetuses, levels in the posterior, anterior and whole pituitary increased exponentially between 39 and 70 days of gestation; in all cases, the increases were close to 35-fold in terms of ng/lobe, and 6-fold in ng/mg of lyophilized tissue. The increases were due to growth, and to an increased accumulation within the tissues. Ratios of activity in the posterior pituitary: anterior pituitary: hypothalamus approximated 200:30:1 (ng/mg of dry tissue). Fetal plasma levels showed some scatter; however, there were no trends with age, and the average value (10.0 +/- 1.6 ng/ml) was close to that of the mothers (10.6 +/- 2.6 ng/ml). Plasma activity appeared to fall markedly around birth; newborn pups, 2-6 hours after birth, showed levels 65% below those of the fetuses, and also below those of the adults (significant; P less than 0.05). At the same time the pituitary levels increased; this suggested a shut-down in release. The possible implications of this in the birth processes are discussed. Amniotic fluid showed only low, inconsistent activity, below 1% of plasma levels. |
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Authors:
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H N Bryant; A M Perks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of developmental physiology Volume: 4 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 139-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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physiology* Animals Animals, Newborn / physiology* Blood Physiological Phenomena* Female Fetus / physiology* Guinea Pigs Melanocyte-Stimulating Hormones / physiology* Pituitary Gland / physiology* Pregnancy |
| Chemical | |
Reg. No./Substance:
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9002-79-3/Melanocyte-Stimulating Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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