Document Detail

Melanocyte-stimulating activity in fetal, newborn and adult guinea-pigs: studies of the pituitary, blood plasma and amniotic fluid.
MedLine Citation:
PMID:  7142674     Owner:  NLM     Status:  MEDLINE    
Melanocyte-stimulating activity in the pituitary and plasma of fetal, newborn and adult guinea-pigs, and in amniotic fluid, was bioassayed on isolated Anolis skin. In the fetuses, levels in the posterior, anterior and whole pituitary increased exponentially between 39 and 70 days of gestation; in all cases, the increases were close to 35-fold in terms of ng/lobe, and 6-fold in ng/mg of lyophilized tissue. The increases were due to growth, and to an increased accumulation within the tissues. Ratios of activity in the posterior pituitary: anterior pituitary: hypothalamus approximated 200:30:1 (ng/mg of dry tissue). Fetal plasma levels showed some scatter; however, there were no trends with age, and the average value (10.0 +/- 1.6 ng/ml) was close to that of the mothers (10.6 +/- 2.6 ng/ml). Plasma activity appeared to fall markedly around birth; newborn pups, 2-6 hours after birth, showed levels 65% below those of the fetuses, and also below those of the adults (significant; P less than 0.05). At the same time the pituitary levels increased; this suggested a shut-down in release. The possible implications of this in the birth processes are discussed. Amniotic fluid showed only low, inconsistent activity, below 1% of plasma levels.
H N Bryant; A M Perks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  4     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-51     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / physiology*
Animals, Newborn / physiology*
Blood Physiological Phenomena*
Fetus / physiology*
Guinea Pigs
Melanocyte-Stimulating Hormones / physiology*
Pituitary Gland / physiology*
Reg. No./Substance:
9002-79-3/Melanocyte-Stimulating Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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