| Melanocortin signaling in the CNS directly regulates circulating cholesterol. | |
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MedLine Citation:
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PMID: 20526334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesterol circulates in the blood in association with triglycerides and other lipids, and elevated blood low-density lipoprotein cholesterol carries a risk for metabolic and cardiovascular disorders, whereas high-density lipoprotein (HDL) cholesterol in the blood is thought to be beneficial. Circulating cholesterol is the balance among dietary cholesterol absorption, hepatic synthesis and secretion, and the metabolism of lipoproteins by various tissues. We found that the CNS is also an important regulator of cholesterol in rodents. Inhibiting the brain's melanocortin system by pharmacological, genetic or endocrine mechanisms increased circulating HDL cholesterol by reducing its uptake by the liver independent of food intake or body weight. Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver. |
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Authors:
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Diego Perez-Tilve; Susanna M Hofmann; Joshua Basford; Ruben Nogueiras; Paul T Pfluger; James T Patterson; Erin Grant; Hilary E Wilson-Perez; Norman A Granholm; Myrtha Arnold; James L Trevaskis; Andrew A Butler; William S Davidson; Stephen C Woods; Stephen C Benoit; Mark W Sleeman; Richard D DiMarchi; David Y Hui; Matthias H Tschöp |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-06 |
Journal Detail:
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Title: Nature neuroscience Volume: 13 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-28 Completed Date: 2010-07-30 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 877-82 Citation Subset: IM |
Affiliation:
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Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD36 / metabolism Body Weight Cholesterol, HDL / blood* Eating Ghrelin / genetics, physiology* Glucagon-Like Peptide 1 / physiology Homeostasis / physiology Hypothalamus / metabolism* Liver / metabolism* Melanocortins / metabolism* Mice Mice, Knockout Neurosecretory Systems / metabolism Rats Rats, Wistar Receptors, Melanocortin / genetics, physiology Scavenger Receptors, Class B / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5R01DK077975/DK/NIDDK NIH HHS; HL67093/HL/NHLBI NIH HHS; NIDDK56863//PHS HHS; R01 DK073189-06/DK/NIDDK NIH HHS; R01 DK076907/DK/NIDDK NIH HHS; R01 HL067093-08/HL/NHLBI NIH HHS; R21 HL104136-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD36; 0/Cholesterol, HDL; 0/Ghrelin; 0/Melanocortins; 0/Receptors, Melanocortin; 0/Scavenger Receptors, Class B; 89750-14-1/Glucagon-Like Peptide 1 |
| Comments/Corrections | |
Comment In:
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Nat Neurosci. 2010 Jul;13(7):779-80
[PMID:
20581809
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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