| Melanocortin receptors form constitutive homo- and heterodimers. | |
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MedLine Citation:
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PMID: 15582585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A significant number of G protein-coupled receptors are shown to form homo- or heterodimers/oligomers, and oligomerization of GPCRs may be a quite general phenomenon. We have here explored the possibility that the two closely related human melanocortin receptor 1 (MC(1)R) and melanocortin receptor 3 (MC(3)R) form dimers. Using bioluminescence resonance energy transfer (BRET(2)) we demonstrate that MC(1) and MC(3)Rs form homo- and heterodimers, when expressed in Cos-7 cells. Treatment with agonist, partial agonist or antagonists did not modify the BRET(2) signal for any of the receptor pairs studied, suggesting that the dimerization is not regulated by ligand binding. Rather our results indicate that melanocortin receptors exist as constitutively pre-formed dimers. |
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Authors:
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Ilona Mandrika; Ramona Petrovska; Jarl Wikberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 326 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-07 Completed Date: 2005-01-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 349-54 Citation Subset: IM |
Affiliation:
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Division of Pharmacology, Department of Pharmaceutical Biosciences, Uppsala University, SE-751 24 Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals COS Cells Cercopithecus aethiops Dimerization Energy Transfer Humans Ligands Protein Structure, Quaternary Radioligand Assay Receptor, Melanocortin, Type 1 / chemistry*, genetics, metabolism* Receptor, Melanocortin, Type 3 / chemistry*, genetics, metabolism* Spectrometry, Fluorescence |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Receptor, Melanocortin, Type 1; 0/Receptor, Melanocortin, Type 3 |
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