Document Detail


Melanin-concentrating hormone functions in the nervous system: food intake and stress.
MedLine Citation:
PMID:  12885269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, which centrally regulates food intake and stress. MCH induces food intake in rodents and, more generally, acts as an anabolic signal in energy regulation. In addition, MCH seems to be activatory on the stress axis. Two receptors for MCH in humans have very recently been characterised, namely, MCH-R1 and MCH-R2. MCH-R1 has received considerable attention, as potent and selective antagonists acting at that receptor display anxiolytic, antidepressant and/or anorectic properties. Feeding and affective disorders are both debilitating conditions that have become serious worldwide health threats. There are as yet no efficient and/or safe cures that could contain the near-pandemia phenomen of both diseases. Thus, the discovery of MCH-R1 antagonists may lead to the development of valuable drugs to treat obesity, anxiety and depressive syndromes. In addition, it opens wide avenues to probe additional functions of the peptide, both in the brain and in the peripheral nervous system.
Authors:
Guillaume Hervieu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  7     ISSN:  1744-7631     ISO Abbreviation:  Expert Opin. Ther. Targets     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-29     Completed Date:  2005-12-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  England    
Other Details:
Languages:  eng     Pagination:  495-511     Citation Subset:  IM    
Affiliation:
GlaxoSmithKline R&D, Drug Discovery, Neurology Centre of Excellence for Drug Discovery, New Frontiers Science Park - North, HW1713 Building H17, L1-130 C06 Third Avenue, Harlow, Essex CM19 5AW, UK. guillaume_hervieu-1@gsk.com
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Appetite / drug effects,  physiology
Brain / metabolism*
Circadian Rhythm
Dogs
Eating / drug effects,  physiology*
Eating Disorders / drug therapy,  epidemiology,  physiopathology
Energy Intake / drug effects,  physiology
Energy Metabolism
Ferrets
Humans
Hypothalamic Hormones / physiology*
Hypothalamo-Hypophyseal System / drug effects,  physiopathology
Melanins / physiology*
Mice
Molecular Sequence Data
Pineal Gland / drug effects,  physiopathology
Pituitary Hormones / physiology*
Pituitary-Adrenal System / drug effects,  physiopathology
Primates
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors, Pituitary Hormone / drug effects,  physiology
Stress, Physiological / drug therapy,  epidemiology,  physiopathology*
Chemical
Reg. No./Substance:
0/Hypothalamic Hormones; 0/Melanins; 0/Pituitary Hormones; 0/Receptors, Pituitary Hormone; 0/melanin-concentrating hormone receptor; 67382-96-1/melanin-concentrating hormone

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