|Melanin-concentrating hormone functions in the nervous system: food intake and stress.|
|PMID: 12885269 Owner: NLM Status: MEDLINE|
|Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, which centrally regulates food intake and stress. MCH induces food intake in rodents and, more generally, acts as an anabolic signal in energy regulation. In addition, MCH seems to be activatory on the stress axis. Two receptors for MCH in humans have very recently been characterised, namely, MCH-R1 and MCH-R2. MCH-R1 has received considerable attention, as potent and selective antagonists acting at that receptor display anxiolytic, antidepressant and/or anorectic properties. Feeding and affective disorders are both debilitating conditions that have become serious worldwide health threats. There are as yet no efficient and/or safe cures that could contain the near-pandemia phenomen of both diseases. Thus, the discovery of MCH-R1 antagonists may lead to the development of valuable drugs to treat obesity, anxiety and depressive syndromes. In addition, it opens wide avenues to probe additional functions of the peptide, both in the brain and in the peripheral nervous system.|
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|Type: Journal Article; Review|
|Title: Expert opinion on therapeutic targets Volume: 7 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2003 Aug|
|Created Date: 2003-07-29 Completed Date: 2005-12-13 Revised Date: 2008-11-21|
Medline Journal Info:
|Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England|
|Languages: eng Pagination: 495-511 Citation Subset: IM|
|GlaxoSmithKline R&D, Drug Discovery, Neurology Centre of Excellence for Drug Discovery, New Frontiers Science Park - North, HW1713 Building H17, L1-130 C06 Third Avenue, Harlow, Essex CM19 5AW, UK. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Amino Acid Sequence
Appetite / drug effects, physiology
Brain / metabolism*
Eating / drug effects, physiology*
Eating Disorders / drug therapy, epidemiology, physiopathology
Energy Intake / drug effects, physiology
Hypothalamic Hormones / physiology*
Hypothalamo-Hypophyseal System / drug effects, physiopathology
Melanins / physiology*
Molecular Sequence Data
Pineal Gland / drug effects, physiopathology
Pituitary Hormones / physiology*
Pituitary-Adrenal System / drug effects, physiopathology
Receptors, Pituitary Hormone / drug effects, physiology
Stress, Physiological / drug therapy, epidemiology, physiopathology*
|0/Hypothalamic Hormones; 0/Melanins; 0/Pituitary Hormones; 0/Receptors, Pituitary Hormone; 0/melanin-concentrating hormone receptor; 67382-96-1/melanin-concentrating hormone|
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