| Melanin as an adsorbent for drug residues. | |
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MedLine Citation:
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PMID: 7879877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The binding of seven veterinary drugs (clenbuterol, chlorpromazine, diethylstilbestrol, 19-nortestosterone, salbutamol, salicylic acid and trenbolone) to melanin from Sepia officinalis was investigated. Basic and hydrophobic drugs were the most strongly bound. Desorption by ethanol was complete for neutral drugs but only partial for the basic drugs, which suggests that binding of the latter involves an ionic component. A method of synthesizing melanin in an immobilized form (melanin-PS) on the surface of porous silica was developed. When the drug binding properties of melanin-PS were investigated, its capacity to bind the basic drug clenbuterol was found to be higher (5.9 nmol mg-1) than that for the neutral hydrophobic drug 19-nortestosterone (0.56 nmol mg-1); for both drugs the attainment of binding equilibrium with melanin-PS was relatively rapid (< 5 min). By virtue of its binding kinetics, high capacity and mechanical robustness, melanin-PS offers potential for use in chromatography or solid-phase extraction and may additionally enable modelling of drug-melanin interactions. |
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Authors:
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L Howells; M Godfrey; M J Sauer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Analyst Volume: 119 ISSN: 0003-2654 ISO Abbreviation: Analyst Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-03-31 Completed Date: 1995-03-31 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372652 Medline TA: Analyst Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2691-3 Citation Subset: IM |
Affiliation:
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Biochemistry Department, Central Veterinary Laboratory, Addlestone, Surrey, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Albuterol / isolation & purification Animals Clenbuterol / isolation & purification Diethylstilbestrol / isolation & purification Drug Residues* / analysis, isolation & purification Melanins* Methods Nandrolone / isolation & purification Salicylic Acid Salicylic Acids / isolation & purification Sensitivity and Specificity Trenbolone / isolation & purification Veterinary Medicine |
| Chemical | |
Reg. No./Substance:
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0/Melanins; 0/Salicylic Acids; 10161-33-8/Trenbolone; 18559-94-9/Albuterol; 37148-27-9/Clenbuterol; 434-22-0/Nandrolone; 56-53-1/Diethylstilbestrol; 69-72-7/Salicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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