Document Detail

Melanin as an adsorbent for drug residues.
MedLine Citation:
PMID:  7879877     Owner:  NLM     Status:  MEDLINE    
The binding of seven veterinary drugs (clenbuterol, chlorpromazine, diethylstilbestrol, 19-nortestosterone, salbutamol, salicylic acid and trenbolone) to melanin from Sepia officinalis was investigated. Basic and hydrophobic drugs were the most strongly bound. Desorption by ethanol was complete for neutral drugs but only partial for the basic drugs, which suggests that binding of the latter involves an ionic component. A method of synthesizing melanin in an immobilized form (melanin-PS) on the surface of porous silica was developed. When the drug binding properties of melanin-PS were investigated, its capacity to bind the basic drug clenbuterol was found to be higher (5.9 nmol mg-1) than that for the neutral hydrophobic drug 19-nortestosterone (0.56 nmol mg-1); for both drugs the attainment of binding equilibrium with melanin-PS was relatively rapid (< 5 min). By virtue of its binding kinetics, high capacity and mechanical robustness, melanin-PS offers potential for use in chromatography or solid-phase extraction and may additionally enable modelling of drug-melanin interactions.
L Howells; M Godfrey; M J Sauer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Analyst     Volume:  119     ISSN:  0003-2654     ISO Abbreviation:  Analyst     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-03-31     Completed Date:  1995-03-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2691-3     Citation Subset:  IM    
Biochemistry Department, Central Veterinary Laboratory, Addlestone, Surrey, UK.
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MeSH Terms
Albuterol / isolation & purification
Clenbuterol / isolation & purification
Diethylstilbestrol / isolation & purification
Drug Residues* / analysis,  isolation & purification
Nandrolone / isolation & purification
Salicylic Acid
Salicylic Acids / isolation & purification
Sensitivity and Specificity
Trenbolone / isolation & purification
Veterinary Medicine
Reg. No./Substance:
0/Melanins; 0/Salicylic Acids; 10161-33-8/Trenbolone; 18559-94-9/Albuterol; 37148-27-9/Clenbuterol; 434-22-0/Nandrolone; 56-53-1/Diethylstilbestrol; 69-72-7/Salicylic Acid

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