| Melampomagnolide B: A new antileukemic sesquiterpene. | |
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MedLine Citation:
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PMID: 21273084 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Melampomagnolide B has been identified as a new antileukemic sesquiterpene. A biotin-conjugated derivative of melampomagnolide B was designed and synthesized in order to elucidate its mechanism of action. A study of the biochemical interactions of the biotin probe suggests that melampomagnolide B derives its remarkable selectivity for leukemic cells over normal hematopoietic cells from its unique ability to exploit biochemical differences between the two cell types. |
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Authors:
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Shama Nasim; Shanshan Pei; Fred K Hagen; Craig T Jordan; Peter A Crooks |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-6 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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