Document Detail


Melamine-induced infant urinary calculi: a report on 24 cases and a 1-year follow-up.
MedLine Citation:
PMID:  20517603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Melamine has been the main factor leading to infant urinary calculi occurring on a rather wide scale in China in 2008, which were the results of a rapid aggradation of metabolites such as cyanuric acid diamide, cyanuric acid, etc., causing uric acid stone to accumulate. Here, we present a report on 24 infants who were admitted to our department, their ages ranging from 3 to 10 months. All of these infants had a confirmed history of having been fed with the "Sanlu" brand milk powder, which contained excessive levels of melamine, with the highest being 2,563 mg/kg. The diagnosis, medical treatment and follow-up by ultrasonography at 1, 3, 6, 12 months were reported. 22 cases of these infants were rehabilitated after medical treatment and 1 infant underwent pyelolithotomy for relieving an obvious ureter obstruction. No recurrence was found in these babies thereafter. Another infant died from rapidly worsening renal failure. Therefore, this series of cases have demonstrated that melamine contained in the "Sanlu" milk powder was the main cause of these urinary stones. Urine alkalinization and stone liberalization were the most effective treatments. Fast diagnosis and treatment of acute obstructive urolithiasis may prevent the development of acute renal failure, which is associated with high morbidity and mortality rates.
Authors:
Xiangbo Zhang; Jinliang Bai; Pengcheng Ma; Jianhua Ma; Jianghou Wan; Bin Jiang
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-06-02
Journal Detail:
Title:  Urological research     Volume:  38     ISSN:  1434-0879     ISO Abbreviation:  Urol. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  IM    
Affiliation:
Department of Urology, The First Hospital of LanZhou University, West DongGang Road, ChengGuan District, Lanzhou City, 730000, Gansu, China. zhangxb2006@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Female
Follow-Up Studies
Humans
Infant
Male
Time Factors
Triazines / adverse effects*
Urinary Calculi / chemically induced*
Chemical
Reg. No./Substance:
0/Triazines; 108-78-1/melamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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