| Melamine-Induced Urolithiasis in a Drosophila Model. | |
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MedLine Citation:
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PMID: 22352299 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Melamine-tainted food can induce renal stones in both humans and animals. We have previously reported a novel Drosophila model for the study of renal stone disease. In addition to hyperoxaluria-causing agents, we also tested herein the effect of melamine on crystal formation in Drosophila . The results indicate that administration of melamine alone caused crystal formation in a dose-dependent manner. The crystals also appeared after ingestion of melamine for 3 weeks in the Malpighian tubules of Drosophila when viewed with polarized light. Administration of potassium citrate (K citrate) was found to significantly ameliorate the melamine-induced reduction of lifespan. However, administration of K citrate failed to reduce the quantity of crystals. Because calcium oxalate is not the major crystal induced by melamine, the predominant components of melamine-induced crystals and the potential crystal inhibitors warrant further investigation. |
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Authors:
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Wen-Chi Chen; Wei-Yong Lin; Huey-Yi Chen; Chiao-Hui Chang; Fuu-Jen Tsai; Kee-Ming Man; Jui-Lung Shen; Yung-Hsiang Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-1 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University , Taichung 40402, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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