| Meiotic delay of mouse spermatocytes carrying x-ray-induced translocations. | |
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MedLine Citation:
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PMID: 1611914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kinetics of spermatocyte progression through meiotic prophase in cells with or without induced translocations were studied in mice that had been exposed to x-rays. Pulse-labeling experiments using 3H-thymidine, followed by autoradiographic analysis, indicated that at higher x-ray doses (6 and 7 Gy), translocation-carrying cells tend to spend more time in meiotic prophase than do normal cells. At 2 Gy, no such delay seemed to be present. The observed delay may explain the reduction in transmission of translocations to the next generation reported by others. |
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Authors:
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P P van Buul; C M Seelen; J H Goudzwaard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cytogenetics and cell genetics Volume: 60 ISSN: 0301-0171 ISO Abbreviation: Cytogenet. Cell Genet. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-07-29 Completed Date: 1992-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367735 Medline TA: Cytogenet Cell Genet Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 146-9 Citation Subset: IM |
Affiliation:
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MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Radiation Male Meiosis / genetics, radiation effects* Mice Prophase / genetics, radiation effects* Spermatocytes / physiology, radiation effects* Translocation, Genetic / genetics, radiation effects* |
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