| Megestrol acetate for treatment of endometriosis. | |
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MedLine Citation:
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PMID: 2314784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1977-1989, 29 women with symptomatic endometriosis were treated with megestrol acetate by the Johns Hopkins Division of Reproductive Endocrinology. All had previously received one or more alternative medical treatments for endometriosis, in each case discontinued because of poor response or development of unacceptable side effects. Treatment consisted of a daily dose of 40 mg megestrol acetate orally for up to 24 months. Disease-related symptoms (dysmenorrhea, noncyclic pelvic pain, and dyspareunia) were relieved in 86% of the subjects treated with an adequate course of therapy. Side effects were fairly well tolerated, although eight women discontinued treatment within 2 months and two others stopped the drug by 4 months. These preliminary findings suggest that megestrol acetate may be an effective treatment for patients with endometriosis, even those who have been unresponsive to other modes of therapy. |
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Authors:
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W D Schlaff; L Dugoff; M D Damewood; J A Rock |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 75 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-04-26 Completed Date: 1990-04-26 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 646-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Endometriosis / drug therapy* Female Humans Megestrol / adverse effects, analogs & derivatives*, therapeutic use Megestrol Acetate Middle Aged Pelvic Neoplasms / drug therapy* |
| Chemical | |
Reg. No./Substance:
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3562-63-8/Megestrol; 51154-23-5/Megestrol Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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