Document Detail


Megestrol acetate increases short-term food intake in zinc-deficient rats.
MedLine Citation:
PMID:  11897258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats offered a zinc-deficient (-Zn) diet voluntarily reduce their food intake within 3-4 days. Megestrol acetate (MA) is an appetite-stimulating drug used to treat cachexia of chronic diseases. In previous work, we found MA administration to male rats increased consumption of a -Zn diet. This approach would provide a useful tool for nutritional studies in which nutrient intake, except for zinc, would be maintained. The present study further examined the use of MA to increase consumption of a -Zn diet over a longer time period in both male and female rats. Rats were fed either a -Zn or a zinc-adequate (+Zn) diet. In Experiment 1, rats were treated orally with 0, 20, 50 or 100 mg MA/kg BW in corn oil for 21 days. MA stimulated intake of the -Zn diet in a linear manner. In Experiments 2 and 3, male and female rats, respectively, were fed the -Zn or +Zn diets and treated with 100 mg MA/kg BW for 21 days. In both experiments, MA administration increased intake of the -Zn diet to levels similar to the +Zn diet through Day 14. MA increased the hypothalamic neuropeptide Y (NPY) concentration in male rats, but did not affect serum IGF-I. MA administration improved growth of female but not male rats fed the -Zn diet. In females, serum IGF-I was not lower in zinc-deficient rats, which may have allowed the improved growth response with MA. Hence, MA administration may be a useful tool to increase consumption of a -Zn diet in short-term studies.
Authors:
Patricia S Williamson; Jimmy D Browning; Ruth S MacDonald
Related Documents :
3798368 - 6-mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat.
18632258 - Inflammatory and functional effects of increasing asthma treatment with formoterol or d...
21348878 - Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss...
4038738 - Effects of marginal zinc deficiency on subclinical lead toxicity in the rat neonate.
8037828 - Hospital employee cholesterol screening: modification of dietary behavior.
14679168 - The bridging function of hepatic lipase clears plasma cholesterol in ldl receptor-defic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  75     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Stimulants / pharmacology*
Diet
Eating / drug effects*
Energy Metabolism / drug effects
Female
Hypothalamus / drug effects,  metabolism
Insulin-Like Growth Factor I / metabolism
Male
Megestrol Acetate / pharmacology*
Neuropeptide Y / metabolism
Organ Size / drug effects,  physiology
Radioimmunoassay
Rats
Rats, Wistar
Sex Characteristics
Weight Gain / drug effects
Zinc / deficiency*
Chemical
Reg. No./Substance:
0/Appetite Stimulants; 0/Neuropeptide Y; 51154-23-5/Megestrol Acetate; 67763-96-6/Insulin-Like Growth Factor I; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intake and hedonics of calcium and sodium during pregnancy and lactation in the rat.
Next Document:  Efficacy of a 'functional energy drink' in counteracting driver sleepiness.