| Megestrol acetate increases short-term food intake in zinc-deficient rats. | |
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MedLine Citation:
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PMID: 11897258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats offered a zinc-deficient (-Zn) diet voluntarily reduce their food intake within 3-4 days. Megestrol acetate (MA) is an appetite-stimulating drug used to treat cachexia of chronic diseases. In previous work, we found MA administration to male rats increased consumption of a -Zn diet. This approach would provide a useful tool for nutritional studies in which nutrient intake, except for zinc, would be maintained. The present study further examined the use of MA to increase consumption of a -Zn diet over a longer time period in both male and female rats. Rats were fed either a -Zn or a zinc-adequate (+Zn) diet. In Experiment 1, rats were treated orally with 0, 20, 50 or 100 mg MA/kg BW in corn oil for 21 days. MA stimulated intake of the -Zn diet in a linear manner. In Experiments 2 and 3, male and female rats, respectively, were fed the -Zn or +Zn diets and treated with 100 mg MA/kg BW for 21 days. In both experiments, MA administration increased intake of the -Zn diet to levels similar to the +Zn diet through Day 14. MA increased the hypothalamic neuropeptide Y (NPY) concentration in male rats, but did not affect serum IGF-I. MA administration improved growth of female but not male rats fed the -Zn diet. In females, serum IGF-I was not lower in zinc-deficient rats, which may have allowed the improved growth response with MA. Hence, MA administration may be a useful tool to increase consumption of a -Zn diet in short-term studies. |
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Authors:
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Patricia S Williamson; Jimmy D Browning; Ruth S MacDonald |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Physiology & behavior Volume: 75 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-18 Completed Date: 2002-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 323-30 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Stimulants / pharmacology* Diet Eating / drug effects* Energy Metabolism / drug effects Female Hypothalamus / drug effects, metabolism Insulin-Like Growth Factor I / metabolism Male Megestrol Acetate / pharmacology* Neuropeptide Y / metabolism Organ Size / drug effects, physiology Radioimmunoassay Rats Rats, Wistar Sex Characteristics Weight Gain / drug effects Zinc / deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Appetite Stimulants; 0/Neuropeptide Y; 51154-23-5/Megestrol Acetate; 67763-96-6/Insulin-Like Growth Factor I; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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