Document Detail

Megestrol acetate increases short-term food intake in zinc-deficient rats.
MedLine Citation:
PMID:  11897258     Owner:  NLM     Status:  MEDLINE    
Rats offered a zinc-deficient (-Zn) diet voluntarily reduce their food intake within 3-4 days. Megestrol acetate (MA) is an appetite-stimulating drug used to treat cachexia of chronic diseases. In previous work, we found MA administration to male rats increased consumption of a -Zn diet. This approach would provide a useful tool for nutritional studies in which nutrient intake, except for zinc, would be maintained. The present study further examined the use of MA to increase consumption of a -Zn diet over a longer time period in both male and female rats. Rats were fed either a -Zn or a zinc-adequate (+Zn) diet. In Experiment 1, rats were treated orally with 0, 20, 50 or 100 mg MA/kg BW in corn oil for 21 days. MA stimulated intake of the -Zn diet in a linear manner. In Experiments 2 and 3, male and female rats, respectively, were fed the -Zn or +Zn diets and treated with 100 mg MA/kg BW for 21 days. In both experiments, MA administration increased intake of the -Zn diet to levels similar to the +Zn diet through Day 14. MA increased the hypothalamic neuropeptide Y (NPY) concentration in male rats, but did not affect serum IGF-I. MA administration improved growth of female but not male rats fed the -Zn diet. In females, serum IGF-I was not lower in zinc-deficient rats, which may have allowed the improved growth response with MA. Hence, MA administration may be a useful tool to increase consumption of a -Zn diet in short-term studies.
Patricia S Williamson; Jimmy D Browning; Ruth S MacDonald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  75     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.
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MeSH Terms
Appetite Stimulants / pharmacology*
Eating / drug effects*
Energy Metabolism / drug effects
Hypothalamus / drug effects,  metabolism
Insulin-Like Growth Factor I / metabolism
Megestrol Acetate / pharmacology*
Neuropeptide Y / metabolism
Organ Size / drug effects,  physiology
Rats, Wistar
Sex Characteristics
Weight Gain / drug effects
Zinc / deficiency*
Reg. No./Substance:
0/Appetite Stimulants; 0/Neuropeptide Y; 51154-23-5/Megestrol Acetate; 67763-96-6/Insulin-Like Growth Factor I; 7440-66-6/Zinc

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