Document Detail

Megalin and the neurodevelopmental biology of sonic hedgehog and retinol.
MedLine Citation:
PMID:  12584240     Owner:  NLM     Status:  MEDLINE    
Megalin is a receptor expressed by embryonic epithelia that mediates endocytosis of numerous ligands, including sonic hedgehog (Shh) and retinol, the precursor to retinoic acid (RA). The importance of Shh and RA signaling in neurodevelopment, combined with the fact that megalin-deficient mice show profound neurodevelopmental abnormalities, has raised questions as to the possible role of megalin in Shh and RA signaling. Several mechanisms could explain how megalin influences Shh and RA signaling in the context of neurodevelopment. These include the involvement of megalin in the transport of Shh and retinol within neuroepithelia, as well as direct signal transduction as a response to binding of Shh and retinol to megalin.
Robert A McCarthy; W Scott Argraves
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  116     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-13     Completed Date:  2003-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  955-60     Citation Subset:  IM    
Medical University of South Carolina, Department of Cell Biology, 171 Ashley Avenue, Charleston, SC 29425-2204, USA.
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MeSH Terms
Epithelial Cells / physiology
Gene Expression Regulation, Developmental
Hedgehog Proteins
LDL-Receptor Related Protein 2 / genetics*,  metabolism
Nervous System / cytology,  embryology*
Signal Transduction / physiology
Trans-Activators / genetics*,  metabolism
Vitamin A / metabolism*
Reg. No./Substance:
0/Hedgehog Proteins; 0/LDL-Receptor Related Protein 2; 0/SHH protein, human; 0/Trans-Activators; 11103-57-4/Vitamin A

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