| Megalencephalic leukodystrophy in an Asian Indian ethnic group. | |
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MedLine Citation:
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PMID: 8805171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over a 10-year period, we reviewed 30 patients with leukodystrophy, megalencephaly, and a relatively benign course. Most of these patients (26) belonged to a distinctive ethnic group called the Agrawals. Head circumference exceeded the 95th percentile in 28 patients; 22 patients had seizures; 22 had pyramidal signs (16 more pronounced and 6 mild); and 16 had cerebellar ataxia. The median age of onset of symptoms was 1.8 years. Interictal electroencephalogram (EEG) was abnormal in 21 of 23 patients. The inheritance is possibly autosomal recessive. |
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Authors:
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B S Singhal; R D Gursahani; V P Udani; A A Biniwale |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 14 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Bombay Hospital Institute of Medical Sciences, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / abnormalities* Child Child, Preschool Cognition Disorders / diagnosis, genetics* Diffuse Cerebral Sclerosis of Schilder / diagnosis, genetics* Electroencephalography Ethnic Groups / genetics* Female Humans India Infant Magnetic Resonance Imaging Male Middle Aged Retrospective Studies Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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