Document Detail

Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells.
MedLine Citation:
PMID:  17490721     Owner:  NLM     Status:  MEDLINE    
After acute infestation with the Chagas disease parasite, Trypanosoma cruzi, some patients who are serologically positive develop chronic megacolon and megaesophagus, whereas others are symptom-free. Chagas disease with gastrointestinal involvement involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons. It is known that glial cells can be involved in enteric inflammatory responses. The aims were to determine the nature of any difference in lymphocytic invasion, enteric neurons, and enteric glial cells in seropositive individuals with and without megacolon. We have compared colonic tissue from serologically positive individuals with and without symptoms and from seronegative controls. Subjects with megacolon had significantly more CD-57 natural killer cells and TIA-1 cytotoxic lymphocytes within enteric ganglia, but numbers of CD-3 and CD-20 immunoreactive cells were not significantly elevated. The innervation of the muscle was substantially reduced to about 20% in megacolon, but asymptomatic seropositive subjects were not different to seronegative controls. Glial cell loss occurred equally in symptomatic and unaffected seropositive subjects, although the proportion with glial fibrillary acidic protein was greater in seropositive, nonsymptomatic subjects. Development of megacolon after acute infection with T cruzi is associated with maintained invasion of enteric ganglia with cytotoxic T cells and loss of muscle innervation, but changes in glial cell numbers are not associated with progression of enteric neuropathy.
Alexandre Barcelos Morais da Silveira; Elenice M Lemos; Sheila J Adad; Rodrigo Correa-Oliveira; John B Furness; Débora D'Avila Reis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-08
Journal Detail:
Title:  Human pathology     Volume:  38     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-20     Completed Date:  2007-09-11     Revised Date:  2008-06-16    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1256-64     Citation Subset:  IM    
Department of Morphology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CEP: 31270-901 Pampulha, Belo Horizonte, Minas Gerais, Brazil.
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MeSH Terms
Biological Markers / metabolism
Cell Count
Chagas Disease / complications,  immunology,  pathology*
Colon / innervation,  pathology*
Fluorescent Antibody Technique, Indirect
Immunoenzyme Techniques
Killer Cells, Natural / metabolism,  pathology
Lymphocyte Subsets / metabolism,  pathology
Megacolon / immunology,  parasitology,  pathology*
Myenteric Plexus / immunology,  pathology*
Neuroglia / immunology,  metabolism,  pathology*
Poly(A)-Binding Proteins / metabolism
Submucous Plexus / immunology,  pathology*
T-Lymphocytes, Cytotoxic / metabolism,  pathology
Reg. No./Substance:
0/Biological Markers; 0/Poly(A)-Binding Proteins; 145138-44-9/TIA1 protein, human
Comment In:
Hum Pathol. 2008 May;39(5):793; author reply 793   [PMID:  18439945 ]

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