Document Detail

Megabase scale restriction fragment length polymorphisms in the human major histocompatibility complex.
MedLine Citation:
PMID:  1979058     Owner:  NLM     Status:  MEDLINE    
Pulsed-field gel electrophoresis of human peripheral blood lymphocyte DNA was used to ascertain the extent of megabase restriction fragment length variation in the HLA region of human chromosome 6 and to determine whether previously reported diversity was due to experimental variation or DNA polymorphism. Polymorphism was found to predominate in the vicinity of the class II DR, class III complement, and the class I A genes and to be limited or absent near the class II DP genes, the TNF genes, and the class I B and C genes. Thus, the MHC region is characterized by both fine and large-scale structural diversity.
S K Lawrance; C L Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  8     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-01-16     Completed Date:  1991-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  394-9     Citation Subset:  IM    
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
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MeSH Terms
Chromosome Mapping
Chromosomes, Human, Pair 6*
Complement System Proteins / genetics
DNA / analysis
Electrophoresis, Polyacrylamide Gel
Genes, MHC Class I
Genes, MHC Class II
Lymphocytes / chemistry
Major Histocompatibility Complex*
Polymorphism, Restriction Fragment Length*
Reg. No./Substance:
9007-36-7/Complement System Proteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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