Document Detail

Meg evaluation of epileptic activity in the time and frequency domain.
MedLine Citation:
PMID:  19132796     Owner:  NLM     Status:  MEDLINE    
We investigated the localization of current sources in the time and frequency domain from spontaneous MEG data recorded from nine epileptic patients (six females; three males) randomly selected, who had a mean age of 41 years old (range of 17-78 years old), with different types of epilepsy. The MEG data were recorded in a magnetically shielded room with a whole-head 122 channel biomagnetometer. For each MEG spike, we calculated the single Equivalent Current Dipole (ECD) sources at the initial spike peaks with a spherical model. MRI and EEG findings were available in patients' records. Prominent low frequencies can be seen in the majority of channels. For each patient there was an increase of the frequency range after the ECD in comparison with the frequency range before the ECD, in the whole study group due to epileptic discharge which is statistically significant (p=0.02). There was also a statistical significant difference in the increase of the frequency range in four patients with pathologic MRI (p=0.05), in five patients with normal MRI (p=0.02), in five patients with a high incidence of seizures (p=0.04) and in four patients with onset<10 years (p=0.04). The MEG analysis of neuromagnetic data gives information about the modification of the frequency range in the epileptic brains.
A Kotini; E Mavraki; P Anninos; H Piperidou; P Prassopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of integrative neuroscience     Volume:  7     ISSN:  0219-6352     ISO Abbreviation:  J. Integr. Neurosci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156357     Medline TA:  J Integr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-80     Citation Subset:  IM    
Laboratory of Medical Physics, Department of Neurology, Medical School, Democritus University of Thrace, Alex/Polis, Greece.
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MeSH Terms
Brain Mapping / methods
Cerebral Cortex / physiopathology*
Electroencephalography / methods
Epilepsy / diagnosis,  physiopathology*
Evoked Potentials / physiology*
Magnetic Resonance Imaging / methods
Magnetoencephalography / methods*
Middle Aged
Predictive Value of Tests
Time Factors
Young Adult

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