| Mefloquine tolerability during chemoprophylaxis: focus on adverse event assessments, stereochemistry and compliance. | |
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MedLine Citation:
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PMID: 8765456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This longitudinal study of travellers to Africa taking mefloquine (MQ) chemoprophylaxis aimed to quantify and assess non-serious adverse events (AE) occurring during short-term prophylaxis and relate these to concentrations of racemic MQ, its enantiomers and metabolite. A total of 420 volunteers (52% F) participated. AEs with some impact on activities were reported by 11.2% of participants including 7.9% of neurological/psychiatric symptoms. Women were more likely to report AEs (P = 0.02). The standardized questionnaires used showed more pathological indicators in travellers who reported subjective AE with significantly more dizziness, distress, sleep disturbances and a high total mood disturbance (TMD) in the AE group. There was, however, no significant performance deficit in computerized psychomotor tests in those experiencing AE. Furthermore, no significant differences were observed in enantiomer ratios, metabolite concentrations, or racemic MQ levels in participants with or without AEs suggesting that these factors are not the main predictors of mefloquine intolerability. |
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Authors:
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P Schlagenhauf; R Steffen; H Lobel; R Johnson; R Letz; A Tschopp; N Vranjes; Y Bergqvist; O Ericsson; U Hellgren; L Rombo; S Mannino; J Handschin; D Stürchler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tropical medicine & international health : TM & IH Volume: 1 ISSN: 1360-2276 ISO Abbreviation: Trop. Med. Int. Health Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-13 Completed Date: 1996-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9610576 Medline TA: Trop Med Int Health Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 485-94 Citation Subset: IM |
Affiliation:
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Institute for Social and Preventive Medicine, University of Zürich. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Africa Drug Tolerance Female Humans Longitudinal Studies Malaria, Falciparum / prevention & control* Male Mefloquine / adverse effects*, chemistry Middle Aged Patient Compliance Questionnaires Sex Factors Stereoisomerism Travel |
| Chemical | |
Reg. No./Substance:
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53230-10-7/Mefloquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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