Document Detail

Meeting report: cGMP matters.
MedLine Citation:
PMID:  18319447     Owner:  NLM     Status:  MEDLINE    
The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) controls many cellular functions ranging from growth to contractility. Generated from guanylyl cyclases in response to natriuretic peptides or nitric oxide, cGMP transduces its effects through a number of cGMP effectors, including cGMP-regulated phosphodiesterases and protein kinases. Drugs that modulate cGMP levels are emerging as promising therapies, particularly for cardiovascular disorders. This report summarizes new data on the molecular mechanisms, (patho)physiological relevance, and therapeutic potential of the cGMP signaling system that were presented at the 3rd cGMP meeting held in June 2007 in Dresden, Germany.
Barbara Kemp-Harper; Robert Feil
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Publication Detail:
Type:  Congresses     Date:  2008-03-04
Journal Detail:
Title:  Science signaling     Volume:  1     ISSN:  1937-9145     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465400     Medline TA:  Sci Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe12     Citation Subset:  IM    
Department of Pharmacology and Centre for Vascular Health, Monash University, Clayton, Victoria, Australia.
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MeSH Terms
Cardiovascular System / metabolism
Cyclic GMP / physiology*
Drug Design
Models, Biological
Peptides / chemistry
Phosphodiesterase Inhibitors / pharmacology
Signal Transduction*
Reg. No./Substance:
0/Peptides; 0/Phosphodiesterase Inhibitors; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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