Document Detail


Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD).
MedLine Citation:
PMID:  17413866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Developmental origins of health and disease (DOHaD) focuses on the earliest stages of human development, and provides a novel paradigm to complement other strategies for lifelong prevention of common chronic health conditions. The 3 International Congress on DOHaD, held in 2005, retained the most popular features from the first two biannual Congresses, while adding a number of innovations, including increased emphasis on implications of DOHaD for the developing world; programs for trainees and young investigators; and new perspectives, including developmental plasticity, influences of social hierarchies, effects of prematurity, and populations in transition. Emerging areas of science included, first, the controversial role of infant weight gain in predicting adult obesity, diabetes, and cardiovascular disease. Second, in the era of epidemic obesity, paying attention to the over-nourished fetus is as important as investigating the growth retarded one. Third, environmental toxins appear to have abroad range of long-lasting effects on the developing human. Fourth, epigenetic mechanisms could unite several strands of human and animal observations, and explain how genetically identical individuals raised in similar postnatal environments can nonetheless develop widely differing phenotypes. Improving the environment to which an individual is exposed during development may be as important as any other public health effort to enhance population health world wide.
Authors:
Matthew W Gillman; David Barker; Dennis Bier; Felino Cagampang; John Challis; Caroline Fall; Keith Godfrey; Peter Gluckman; Mark Hanson; Diana Kuh; Peter Nathanielsz; Penelope Nestel; Kent L Thornburg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-07-16     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Child
Child, Preschool
Congresses as Topic*
Environmental Pollutants
Epigenesis, Genetic
Female
Fetal Development*
Health*
Humans
Infant
Infant, Newborn
Male
Obesity / epidemiology
Grant Support
ID/Acronym/Agency:
G0400519//Medical Research Council; K24 HL 068041/HL/NHLBI NIH HHS; MC_U147585821//Medical Research Council; MC_U147585827//Medical Research Council; MC_UP_A620_1014//Medical Research Council; R13 HD 051239/HD/NICHD NIH HHS; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Environmental Pollutants

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