Document Detail

Medusa head-like granules in squamous cell carcinoma with differentiation toward a hair follicle structure.
MedLine Citation:
PMID:  1939790     Owner:  NLM     Status:  MEDLINE    
A case of squamous cell carcinoma (SCC) with regional lymph node metastasis in a 69-year-old Japanese man is reported. The tumor was characterized by the proliferation of peripheral basaloid, inner squamoid, and glycogen-rich cells, the presence of trichilemmal keratinization, and the presence of ladder-like, membrane-coating granules. These findings suggested that this tumor differentiates toward a hair-follicle structure. The most interesting feature of this tumor was the presence of medusa head-like granules in the cytoplasm of the clear squamoid cells adjacent to the keratinized cells. We have been unable to find any other studies of these granules in squamous cell carcinoma.
O Yamamoto; M Asahi; A Horie; S Fujimoto; K Nakayama
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  18     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-03     Completed Date:  1991-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*,  ultrastructure
Cell Transformation, Neoplastic / pathology*
Cytoplasmic Granules / ultrastructure*
Hair / pathology*,  ultrastructure
Microscopy, Electron
Skin Neoplasms / pathology*,  ultrastructure

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