| Medulloblastoma with melanotic differentiation: case report and review of the literature. | |
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MedLine Citation:
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PMID: 20953660 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in this type of tumor, as well as review clinical outcomes. This subtype of medulloblastoma occurs more frequently in males, at a younger median age than the other subtypes of medulloblastoma. The prognosis is generally very poor. However, it is important to note, that a subset of patients with M0 disease who can achieve a gross total resection followed by radiation and platinum based chemotherapy can become long term survivors of this aggressive subtype of medulloblastoma. |
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Authors:
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Christine L Phillips; Lili Miles; Blaise V Jones; Mary Sutton; Kerry Crone; Maryam Fouladi |
Publication Detail:
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Type: Journal Article Date: 2010-10-16 |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 103 ISSN: 1573-7373 ISO Abbreviation: J. Neurooncol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: United States |
Other Details:
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Languages: eng Pagination: 759-64 Citation Subset: IM |
Affiliation:
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Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA, christine.phillips@cchmc.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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