Document Detail


Medulloblastoma in two successive pregnancies.
MedLine Citation:
PMID:  15933823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 24-year old primaparous female at 20 weeks gestation presented acutely with cerebellar symptoms. Magnetic resonance imaging brain showed evidence of a cerebellar vermis lesion. This was diagnosed as medulloblastoma on histopathological analysis. She underwent surgical debulking and radiotherapy. Interestingly, the lesion recurred 4 years later on her second pregnancy. She underwent further surgical debulking and adjuvant chemotherapy. We believe this is the first reported description of recurrent medulloblastoma in successive pregnancies. A brief discussion on this disease and its management in pregnancy setting is also presented.
Authors:
Albiruni Ryan Abdul Razak; Qasiem Nasser; Patrick Morris; David Alcutt; Liam Grogan
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Publication Detail:
Type:  Case Reports; Letter    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  73     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-03     Completed Date:  2005-10-26     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-90     Citation Subset:  IM    
Affiliation:
Department of Medical Oncology, Beamont Hospital, Dublin, Ireland. albiruni_ryan@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cerebellar Neoplasms / diagnosis*,  drug therapy,  surgery
Chemotherapy, Adjuvant
Cyclophosphamide / therapeutic use
Doxorubicin / therapeutic use
Etoposide / therapeutic use
Female
Humans
Ifosfamide / therapeutic use
Medulloblastoma / diagnosis*,  drug therapy,  surgery
Neoplasm Recurrence, Local / diagnosis*,  drug therapy,  surgery
Pregnancy
Pregnancy Complications, Neoplastic / diagnosis*,  therapy
Treatment Outcome
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
0/IVAD protocol; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide; 3778-73-2/Ifosfamide; 50-18-0/Cyclophosphamide; 57-22-7/Vincristine

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