| Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor. | |
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MedLine Citation:
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PMID: 11516835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypothalamic-pituitary-adrenal axis activation is a hallmark of the stress response. In the case of physical stressors, there is considerable evidence that medullary catecholamine neurones are critical to the activation of the paraventricular nucleus corticotropin-releasing factor cells that constitute the apex of the hypothalamic-pituitary-adrenal axis. In contrast, it has been thought that hypothalamic-pituitary-adrenal axis responses to emotional stressors do not involve brainstem neurones. To investigate this issue we have mapped patterns of restraint-induced neuronal c-fos expression in intact animals and in animals prepared with either paraventricular nucleus-directed injections of a retrograde tracer, lesions of paraventricular nucleus catecholamine terminals, or lesions of the medulla corresponding to the A1 or A2 noradrenergic cell groups. Restraint-induced patterns of neuronal activation within the medulla of intact animals were very similar to those previously reported in response to physical stressors, including the fact that most stressor-responsive, paraventricular nucleus-projecting cells were certainly catecholaminergic and probably noradrenergic. Despite this, the destruction of paraventricular nucleus catecholamine terminals with 6-hydroxydopamine did not alter corticotropin-releasing factor cell responses to restraint. However, animals with ibotenic acid lesions encompassing either the A1 or A2 noradrenergic cell groups displayed significantly suppressed corticotropin-releasing factor cell responses to restraint. Notably, these medullary lesions also suppressed neuronal responses in the medial amygdala, an area that is now considered critical to hypothalamic-pituitary-adrenal axis responses to emotional stressors and that is also known to display a significant increase in noradrenaline turnover during restraint. We conclude that medullary neurones influence corticotropin-releasing factor cell responses to emotional stressors via a multisynaptic pathway that may involve a noradrenergic input to the medial amygdala. These results overturn the idea that hypothalamic-pituitary-adrenal axis response to emotional stressors can occur independently of the brainstem. |
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Authors:
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C V Dayas; K M Buller; T A Day |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience Volume: 105 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2001 |
Date Detail:
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Created Date: 2001-08-22 Completed Date: 2001-11-01 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 707-19 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, 4072, Brisbane, Qld, Australia. c.dayas@mailbox.uq.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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metabolism,
secretion Amygdala / cytology, metabolism* Animals Catecholamines / metabolism Cell Count Corticotropin-Releasing Hormone / metabolism* Denervation Gold Colloid / pharmacokinetics Hypothalamo-Hypophyseal System / cytology, metabolism* Immunohistochemistry Male Medulla Oblongata / cytology, metabolism* Nerve Degeneration / chemically induced Neural Pathways / cytology, metabolism Neurons / cytology, metabolism* Oxidopamine / pharmacology Paraventricular Hypothalamic Nucleus / cytology, metabolism* Presynaptic Terminals / drug effects, metabolism Proto-Oncogene Proteins c-fos / metabolism Rats Rats, Wistar Restraint, Physical / adverse effects Solitary Nucleus / cytology, metabolism Stress, Physiological / metabolism*, physiopathology Wheat Germ Agglutinins / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Gold Colloid; 0/Proto-Oncogene Proteins c-fos; 0/Wheat Germ Agglutinins; 0/wheat germ agglutinin-gold; 1199-18-4/Oxidopamine; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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