Document Detail


Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor.
MedLine Citation:
PMID:  11516835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypothalamic-pituitary-adrenal axis activation is a hallmark of the stress response. In the case of physical stressors, there is considerable evidence that medullary catecholamine neurones are critical to the activation of the paraventricular nucleus corticotropin-releasing factor cells that constitute the apex of the hypothalamic-pituitary-adrenal axis. In contrast, it has been thought that hypothalamic-pituitary-adrenal axis responses to emotional stressors do not involve brainstem neurones. To investigate this issue we have mapped patterns of restraint-induced neuronal c-fos expression in intact animals and in animals prepared with either paraventricular nucleus-directed injections of a retrograde tracer, lesions of paraventricular nucleus catecholamine terminals, or lesions of the medulla corresponding to the A1 or A2 noradrenergic cell groups. Restraint-induced patterns of neuronal activation within the medulla of intact animals were very similar to those previously reported in response to physical stressors, including the fact that most stressor-responsive, paraventricular nucleus-projecting cells were certainly catecholaminergic and probably noradrenergic. Despite this, the destruction of paraventricular nucleus catecholamine terminals with 6-hydroxydopamine did not alter corticotropin-releasing factor cell responses to restraint. However, animals with ibotenic acid lesions encompassing either the A1 or A2 noradrenergic cell groups displayed significantly suppressed corticotropin-releasing factor cell responses to restraint. Notably, these medullary lesions also suppressed neuronal responses in the medial amygdala, an area that is now considered critical to hypothalamic-pituitary-adrenal axis responses to emotional stressors and that is also known to display a significant increase in noradrenaline turnover during restraint. We conclude that medullary neurones influence corticotropin-releasing factor cell responses to emotional stressors via a multisynaptic pathway that may involve a noradrenergic input to the medial amygdala. These results overturn the idea that hypothalamic-pituitary-adrenal axis response to emotional stressors can occur independently of the brainstem.
Authors:
C V Dayas; K M Buller; T A Day
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  105     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-22     Completed Date:  2001-11-01     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  707-19     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, 4072, Brisbane, Qld, Australia. c.dayas@mailbox.uq.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / metabolism,  secretion
Amygdala / cytology,  metabolism*
Animals
Catecholamines / metabolism
Cell Count
Corticotropin-Releasing Hormone / metabolism*
Denervation
Gold Colloid / pharmacokinetics
Hypothalamo-Hypophyseal System / cytology,  metabolism*
Immunohistochemistry
Male
Medulla Oblongata / cytology,  metabolism*
Nerve Degeneration / chemically induced
Neural Pathways / cytology,  metabolism
Neurons / cytology,  metabolism*
Oxidopamine / pharmacology
Paraventricular Hypothalamic Nucleus / cytology,  metabolism*
Presynaptic Terminals / drug effects,  metabolism
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Wistar
Restraint, Physical / adverse effects
Solitary Nucleus / cytology,  metabolism
Stress, Physiological / metabolism*,  physiopathology
Wheat Germ Agglutinins / pharmacokinetics
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Gold Colloid; 0/Proto-Oncogene Proteins c-fos; 0/Wheat Germ Agglutinins; 0/wheat germ agglutinin-gold; 1199-18-4/Oxidopamine; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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