Document Detail

Medullary and mixed medullary-papillary carcinoma of the thyroid gland.
MedLine Citation:
PMID:  9270266     Owner:  NLM     Status:  MEDLINE    
Concurrent medullary and papillary carcinomas of the thyroid gland are rare and occurrence of the medullary and medullary-papillary carcinoma, as far as we know, has not been previously described. The medullary carcinoma was found in the upper part of the right lobe and the mixed medullary-papillary carcinoma in the left lobe of thyroid gland. Immunohistochemistry revealed calcitonin positivity in the medullary parts of the carcinoma and thyroglobulin positivity in papillary structures. Both light microscopy and immunohistochemistry observation distinguished these two cell lineages. The patient was treated with radiotherapy but died 18 months after first symptoms. Metastases were identified in the liver, mediastinal lymph nodes and soft tissues and micro-metastases in the lungs. The authors discuss histogenesis of mixed thyroid carcinomas.
J Macák; H Vaverková; M Dushová; I Perglerová
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathologica     Volume:  89     ISSN:  0031-2983     ISO Abbreviation:  Pathologica     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-10-31     Completed Date:  1997-10-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401123     Medline TA:  Pathologica     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Institute of Pathology of Medical Faculty Palacký University, Czech Republic.
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MeSH Terms
Calcitonin / analysis
Carcinoma, Medullary / pathology*
Carcinoma, Papillary / pathology*
Chromogranins / analysis
Keratins / analysis
Middle Aged
Mucin-1 / analysis
Neoplasm Proteins / analysis
Neoplasms, Multiple Primary / pathology*
Thyroglobulin / analysis
Thyroid Neoplasms / pathology*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Chromogranins; 0/Mucin-1; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 68238-35-7/Keratins; 9007-12-9/Calcitonin; 9010-34-8/Thyroglobulin

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