Document Detail

Medullary carcinoma of the thyroid with atypical patterns.
MedLine Citation:
PMID:  498047     Owner:  NLM     Status:  MEDLINE    
A case of a highly invasive thyroid carcinoma, which occurred in a 68-year-old woman, was studied by light and electron microscopy, and histochemical and biochemical analysis. Light microscopical, histochemical, and biochemical features were consistent with a diagnosis of a calcitonin-producing, amyloid-rich medullary carcinoma; electron microscopical patterns, mainly the presence of lumina, microvilli, and extensively dilated cytoplasmic E.R., were reminiscent of the ultrastructural features of the follicular carcinoma. Electron-dense bodies interpreted as "secretory granules" were very scarce. This case appears very similar to the case recently presented by Valenta et al. and interpreted as a microfollicular carcinoma. The atypical features of our case of MCT seem to indicate that this tumor should be included in a group of atypical MCT; these should be kept separate from the typical (differentiated) ones on morphological, functional, and prognostic grounds.
G Bussolati; G Monga
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  44     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-01-24     Completed Date:  1980-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1769-77     Citation Subset:  AIM; IM    
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MeSH Terms
Amyloid / metabolism
Calcitonin / metabolism
Cytoplasmic Granules / ultrastructure
Endoplasmic Reticulum / ultrastructure
Microscopy, Electron
Serotonin / metabolism
Thyroid Neoplasms / diagnosis,  metabolism,  ultrastructure*
Reg. No./Substance:
0/Amyloid; 50-67-9/Serotonin; 9007-12-9/Calcitonin

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