| Medullar thyroid carcinoma in mediastinum initially presenting as Ectopic ACTH syndrome. A Case Report. | |
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MedLine Citation:
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PMID: 21876495 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A rare case with ectopic adrenocorticotrophic hormone syndrome (EAS) caused by medullar thyroid carcinoma (MTC) in mediastinum was reported. This 49 year-old male patient initially presented with serious and intractable hypokalemia. Endocrine evaluations showed adrenocorticotrophic hormone （ACTH）and urinary free cortisols were at higher levels, and could not be suppressed by more than 50% in high-dose dexamethasone suppression test. Computed tomography (CT) scan detected a 5×5×5cm mass at the bottom of thyroid in anterior mediastinum. Then the patient underwent total thyroidectomy with central compartment and ipsilateral modified radical neck dissection. Pathological examination showed an infiltrating thyroid medullary carcinoma with abundant amyloid deposition, meanwhile immunohistochemical positive for ACTH. After surgery, serum kalium, as well as serum cortisol and ACTH all returned to normal range. During follow-up, the patient's clinical manifestation of Cushing syndrome relived. |
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Authors:
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Xian-Ling Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: Neuro endocrinology letters Volume: 32 ISSN: 0172-780X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008373 Medline TA: Neuro Endocrinol Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China. |
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