| Medium-sized arterial vasculitis associated with vascular deposits of immunoglobin E. Favorable response to intravenous methylprednisolone and cyclophosphamide. | |
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MedLine Citation:
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PMID: 11886722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herein we describe the case of a female patient with medium-sized arterial vasculitis associated with high serum immunoglobin E (lgE) levels in the absence of eosinophilia. During occlusive vascular events, IgE deposits in the arterial muscle layer were demonstrated by immunohistochemistry, suggesting a pathogenic role of this antibody in blood vessel inflammation. Combined treatment with methylprednisolone and cyclophosphamide was successful in reducing serum IgE levels and IgE tissue deposits and in inducing the clinical manifestations of vasculitis into remission. This primary medium-sized IgE-associated vasculitis may constitute a new syndrome not previously reported. |
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Authors:
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Carlos Lavalle; Leopoldo Santos-Argumedo; Angeles Hernández-Cueto; Rosendo Luría-Pérez; César González-Bonilla |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of medical research Volume: 33 ISSN: 0188-4409 ISO Abbreviation: Arch. Med. Res. Publication Date: 2002 Mar-Apr |
Date Detail:
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Created Date: 2002-03-11 Completed Date: 2002-12-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: United States |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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Departamento de Patología Experimental, CINVESTAV del IPN, Ticomán y Av. Instituto Politécnico Nacional, Col. San Pedro Zacatenco, 07360 México City, D.F., México. lavallemontalvo@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / therapeutic use* Arteries / immunology, pathology* Cyclophosphamide / therapeutic use Cytokines / immunology, metabolism Female Flow Cytometry Humans Immunoglobulin E / analysis* Immunosuppressive Agents / therapeutic use Methylprednisolone / therapeutic use* Mexico Vasculitis / drug therapy*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Cytokines; 0/Immunosuppressive Agents; 37341-29-0/Immunoglobulin E; 50-18-0/Cyclophosphamide; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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