| Medium optimization by combination of response surface methodology and desirability function: an application in glutamine production. | |
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MedLine Citation:
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PMID: 17119957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An optimization strategy based on desirability function approach (DFA) together with response surface methodology (RSM) has been used to optimize production medium in L-glutamine fermentation. Fermentation problems often force to reach a compromise between different experimental variables in order to achieve the most suitable strategy applying in industrial production. The importance of the use of multi-objective optimization methods lies in the ability to cope with this kind of problems. A sequential RSM with different combinations of glucose and (NH(4))(2)SO(4) was performed to attain the optimal medium (OM-1) in glutamine production. Based on the result of RSM and the evaluation of production cost, a more economical optimal medium (OM-2) was obtained with the aid of DFA. In DFA study, glutamate, the main by-product in glutamine fermentation as another response was considered. Compared with OM-1 in validated experiment, similar amounts of glutamine were obtained in OM-2 while the concentration of glutamate and the production cost decreased by 53.6 and 7.1%, respectively. |
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Authors:
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Jinshan Li; Cuiqing Ma; Yanhe Ma; Yan Li; Wei Zhou; Ping Xu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-22 |
Journal Detail:
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Title: Applied microbiology and biotechnology Volume: 74 ISSN: 0175-7598 ISO Abbreviation: Appl. Microbiol. Biotechnol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-05-03 Completed Date: 2007-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406612 Medline TA: Appl Microbiol Biotechnol Country: Germany |
Other Details:
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Languages: eng Pagination: 563-71 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biotechnology
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economics,
methods Corynebacterium glutamicum / growth & development, metabolism* Culture Media / chemistry* Fermentation* Glucose / metabolism Glutamic Acid / analysis Glutamine / metabolism* Quaternary Ammonium Compounds / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Quaternary Ammonium Compounds; 50-99-7/Glucose; 56-85-9/Glutamine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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