Document Detail

Medium-chain triglyceride-rich enteral nutrition is more effective than low-fat enteral nutrition in rat colitis, but is equal in enteritis.
MedLine Citation:
PMID:  11686477     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although enteral nutrition (EN) therapy for Crohn's disease has been confirmed to be as effective as steroid therapy, the precise mechanism responsible for the effects of EN remains unclear, although some of the therapeutic effects of EN are believed to be due to a low dietary fat content. In order to elucidate the influence of fat in EN, it is important to investigate not only the quantity of fat, but also the source of the fat. METHODS: We compared two enteral nutritional formulae: Elental (Ajinomoto) (elemental diet; ED), which contains only 1.5% fat, provided as long-chain triglycerides (LCT), versus Twinline (Snow Brand Milk Products) (TL), which contains a high percentage of fat (20.4%), provided mainly as medium-chain triglycerides (MCT). These formulae were tested on rat enteritis and rat colitis induced by trinitrobenzene sulfonic acid (TNBS). RESULTS: Both ED and TL reduced the manifestations of enteritis. TL had a stronger anti-inflammatory effect than ED for colitis. TL also had nutritional advantages as compared with ED, as shown by the total serum protein in the TL group being significantly higher than that in the ED group. CONCLUSION: The results indicate that intraluminal MCT is suitable as a fat energy source during intestinal inflammation in rats. We suggest that Twinline may be more useful to improve nutritional status and to reduce the mucosal inflammation in rat colitis, but that Twinline is equal in effect to Elental for rat enteritis.
T Tsujikawa; N Ohta; T Nakamura; T Yasuoka; J Satoh; T Fukunaga; A Itohi; K Uda; T Ihara; A Andoh; M Sasaki; Y Fujiyama; T Bamba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  36     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-31     Completed Date:  2002-02-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  673-80     Citation Subset:  IM    
Second Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.
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MeSH Terms
Body Weight
Colitis / chemically induced,  diet therapy*,  pathology
Colon / pathology
Disease Models, Animal
Enteral Nutrition / methods*
Enteritis / chemically induced,  diet therapy*,  pathology
Feces / chemistry
Intestines / pathology
Rats, Sprague-Dawley
Trinitrobenzenesulfonic Acid
Reg. No./Substance:
2508-19-2/Trinitrobenzenesulfonic Acid

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