Document Detail

A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change.
MedLine Citation:
PMID:  20352618     Owner:  NLM     Status:  MEDLINE    
Only a few studies have analyzed the effects of the potential interaction between the -174G/C polymorphism of IL6 gene and the adherence to the Mediterranean diet (MD) on adiposity indexes. Our aim was to investigate the interplay between the -174G/C polymorphism of the IL6 gene and a Mediterranean-style diet on body weight changes after 3 years of nutritional intervention in a high cardiovascular risk population. A total of 737 participants, aged 55-80 years were assigned to a low-fat diet or to a Mediterranean-style diet group with high intake of virgin olive oil (VOO) or nuts. Anthropometric measurements were taken at baseline and after 3-year follow-up. The -174G/C polymorphism of the IL6 gene was genotyped. Minor allele frequency (C) was 0.39. At baseline, the CC genotype was associated with higher measures of adiposity. After 3 years, a significant interaction (p=0.028) was found between the polymorphism (GG+GC versus CC) and the nutritional intervention: CC subjects following the MD+VOO had the lowest body weight gain. In conclusion, at baseline, CC subjects for the -174G/C polymorphism of IL6 had the highest body weight and BMI. However, after 3 years of nutritional intervention with MD+VOO, these subjects were predicted to have the greatest reduction in body weight.
Cristina Razquin; J Alfredo Martinez; Miguel A Martinez-Gonzalez; Joaquin Fernández-Crehuet; José Manuel Santos; Amelia Marti
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  54 Suppl 1     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  S75-82     Citation Subset:  IM    
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Spain.
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MeSH Terms
Blood Pressure
Body Mass Index
Body Weight / drug effects
Cardiovascular Diseases / epidemiology
DNA / blood,  genetics,  isolation & purification
Diabetes Mellitus / genetics
Diet, Mediterranean*
Genetic Variation*
Interleukin-6 / genetics*
Middle Aged
Plant Oils / pharmacology*
Polymorphism, Single Nucleotide*
Risk Factors
Reg. No./Substance:
0/Interleukin-6; 0/Plant Oils; 8001-25-0/olive oil; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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