| A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change. | |
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MedLine Citation:
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PMID: 20352618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Only a few studies have analyzed the effects of the potential interaction between the -174G/C polymorphism of IL6 gene and the adherence to the Mediterranean diet (MD) on adiposity indexes. Our aim was to investigate the interplay between the -174G/C polymorphism of the IL6 gene and a Mediterranean-style diet on body weight changes after 3 years of nutritional intervention in a high cardiovascular risk population. A total of 737 participants, aged 55-80 years were assigned to a low-fat diet or to a Mediterranean-style diet group with high intake of virgin olive oil (VOO) or nuts. Anthropometric measurements were taken at baseline and after 3-year follow-up. The -174G/C polymorphism of the IL6 gene was genotyped. Minor allele frequency (C) was 0.39. At baseline, the CC genotype was associated with higher measures of adiposity. After 3 years, a significant interaction (p=0.028) was found between the polymorphism (GG+GC versus CC) and the nutritional intervention: CC subjects following the MD+VOO had the lowest body weight gain. In conclusion, at baseline, CC subjects for the -174G/C polymorphism of IL6 had the highest body weight and BMI. However, after 3 years of nutritional intervention with MD+VOO, these subjects were predicted to have the greatest reduction in body weight. |
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Authors:
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Cristina Razquin; J Alfredo Martinez; Miguel A Martinez-Gonzalez; Joaquin Fernández-Crehuet; José Manuel Santos; Amelia Marti |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 54 Suppl 1 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: S75-82 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Body Mass Index Body Weight / drug effects Cardiovascular Diseases / epidemiology DNA / blood, genetics, isolation & purification Diabetes Mellitus / genetics Diet, Mediterranean* Female Genetic Variation* Genotype Humans Interleukin-6 / genetics* Male Middle Aged Nuts Plant Oils / pharmacology* Polymorphism, Single Nucleotide* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Plant Oils; 8001-25-0/olive oil; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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