| Mediterranean diet reduces senescence-associated stress in endothelial cells. | |
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MedLine Citation:
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PMID: 21894446 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This paper aims to study the effects of the oxidative stress induced by quality and quantity of dietary fat on cellular senescence. Twenty elderly subjects consumed three diets, each for 4 weeks: a saturated fatty acid diet (SFA), a low-fat and high-carbohydrate diet (CHO-ALA), and a Mediterranean diet (MedDiet) enriched in monounsaturated fatty acid following a randomized crossover design. For each diet, we investigated intracellular reactive oxidative species (ROS), cellular apoptosis and telomere length in human umbilical endothelial cells incubated with serum from each patient. MedDiet induced lower intracellular ROS production, cellular apoptosis, and percentage of cell with telomere shortening, compared with the baseline and with SFA and CHO-ALA diets. Dietary fat modulates the oxidative stress in human endothelial cells. MedDiet protects these cells from oxidative stress, prevents cellular senescence and reduces cellular apoptosis. |
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Authors:
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Carmen Marin; Javier Delgado-Lista; Rafael Ramirez; Julia Carracedo; Javier Caballero; Pablo Perez-Martinez; Francisco Miguel Gutierrez-Mariscal; Antonio Garcia-Rios; Nieves Delgado-Casado; Cristina Cruz-Teno; Elena Maria Yubero-Serrano; Francisco Tinahones; Maria Del Mar Malagon; Francisco Perez-Jimenez; Jose Lopez-Miranda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: Age (Dordrecht, Netherlands) Volume: - ISSN: 1574-4647 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101250497 Medline TA: Age (Dordr) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Lipids and Atherosclerosis Unit, Córdoba, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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