Document Detail

Mediterranean diet and n-3 fatty acids in the prevention and treatment of cardiovascular disease.
MedLine Citation:
PMID:  17876197     Owner:  NLM     Status:  MEDLINE    
Consumption of a traditional Mediterranean diet and n-3 polyunsaturated fatty acids (PUFAs) was shown to be effective in reducing the complications of coronary heart disease in randomised controlled trials. Epidemiological studies and controlled trials indicate that plant- and sea-derived n-3 PUFAs are likely to be important mediators of the protection provided by traditional Mediterranean diets. Of note, consumption of marine n-3 PUFAs from fish and other seafood is high in certain Mediterranean countries (Spain, Portugal), but quite low in others (Italy, Greece). A relative insufficiency of dietary marine n-3 PUFAs among Italians might in part explain the results of the GISSI-Prevenzione trial, in which a modest supplementation of eicosapentaenoic acid + docosahexaenoic acid ( approximately 850 mg/day) produced striking reductions in coronary heart disease death (-30%) and sudden cardiac death (-45%) among patients with known heart disease. The protection provided by n-3 PUFAs from both plant and marine sources may be partly dependent on other dietary factors. Plant and marine n-3 PUFAs are likely to be major mediators of the protective effect provided by traditional Mediterranean diets.
Michel de Lorgeril; Patricia Salen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  8 Suppl 1     ISSN:  1558-2027     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-18     Completed Date:  2008-01-24     Revised Date:  2009-05-28    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S38-41     Citation Subset:  IM    
PRETA-TIMC, Equipe Coeur & Nutrition, CNRS UMR 5525-UJF-INP, University Joseph Fourier, Grenoble, France.
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MeSH Terms
Cardiovascular Diseases / therapy*
Clinical Trials as Topic
Diet, Mediterranean*
Fatty Acids, Omega-3 / therapeutic use*
Reg. No./Substance:
0/Fatty Acids, Omega-3

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