Document Detail


The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon.
MedLine Citation:
PMID:  22133197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A Mediterranean diet appears to have health benefits in many domains of human health, mediated perhaps by its anti-inflammatory effects. Metabolism of fatty acids and subsequent eicosanoid production is a key mechanism by which a Mediterranean diet can exert anti-inflammatory effects. Both dietary fatty acids and fatty acid metabolism determine fatty acid availability for cyclooxygenase- and lipoxygenase-dependent production of eicosanoids, namely prostaglandins and leukotrienes. In dietary intervention studies and in observational studies of the Mediterranean diet, blood levels of fatty acids do reflect dietary intakes but are attenuated. Small differences in fatty acid levels, however, appear to be important, especially when exposures occur over long periods of time. This review summarizes how fat intakes from a Greek-style Mediterranean diet can be expected to affect fatty acid metabolizing proteins, with an emphasis on the metabolic pathways that lead to the formation of proinflammatory eicosanoids. The proteins involved in these pathways are ripe for investigation using proteomic approaches and may be targets for colon cancer prevention.
Authors:
Zora Djuric
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  69     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-01-25     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-44     Citation Subset:  IM    
Copyright Information:
© 2011 International Life Sciences Institute.
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MeSH Terms
Descriptor/Qualifier:
Colon / metabolism
Colonic Neoplasms / prevention & control*
Diet, Mediterranean*
Dietary Fats / administration & dosage*,  metabolism
Eicosanoids / metabolism*
Fatty Acids / metabolism*
Humans
Lipoxygenase / metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Grant Support
ID/Acronym/Agency:
1R01 CA120381/CA/NCI NIH HHS; CA046592/CA/NCI NIH HHS; P30 CA046592/CA/NCI NIH HHS; P30 CA046592-23/CA/NCI NIH HHS; R01 CA120381/CA/NCI NIH HHS; R01 CA120381-01A1/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Eicosanoids; 0/Fatty Acids; EC 1.13.11.12/Lipoxygenase; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases
Comments/Corrections

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