| Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. | |
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MedLine Citation:
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PMID: 21788627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort study including 11,994 incident type 2 diabetic case subjects and a stratified subcohort of 15,798 participants selected from a total cohort of 340,234 participants with 3.99 million person-years of follow-up, from eight European cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The relative Mediterranean diet score (rMED) (score range 0-18) was used to assess adherence to MDP on the basis of reported consumption of nine dietary components characteristic of the Mediterranean diet. Cox proportional hazards regression, modified for the case-cohort design, was used to estimate the association between rMED and risk of type 2 diabetes, adjusting for confounders. RESULTS: The multiple adjusted hazard ratios of type 2 diabetes among individuals with medium (rMED 7-10 points) and high adherence to MDP (rMED 11-18 points) were 0.93 (95% CI 0.86-1.01) and 0.88 (0.79-0.97), respectively, compared with individuals with low adherence to MDP (0-6 points) (P for trend 0.013). The association between rMED and type 2 diabetes was attenuated in people <50 years of age, in obese participants, and when the alcohol, meat, and olive oil components were excluded from the score. CONCLUSIONS: In this large prospective study, adherence to the MDP, as defined by rMED, was associated with a small reduction in the risk of developing type 2 diabetes in this European population. |
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Authors:
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; D Romaguera; M Guevara; T Norat; C Lagenberg; N G Forouhi; S Sharp; N Slimani; M B Schulze; B Buijsse; G Buckland; E Molina-Montes; M J Sánchez; M C Moreno-Iribas; B Bendinelli; S Grioni; Y T van der Schouw; L Arriola; J W Beulens; H Boeing; F Clavel-Chapelon; V Cottet; F L Crowe; B de Lauzon-Guillan; P W Franks; C Gonzalez; G Hallmans; R Kaaks; T J Key; K Khaw; P Nilsson; K Overvad; L Palla; D Palli; S Panico; J R Quirós; O Rolandsson; I Romieu; C Sacerdote; A M W Spijkerman; B Teucher; A Tjonneland; M J Tormo; R Tumino; A D L van der; E J M Feskens; E Riboli; N J Wareham |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-25 |
Journal Detail:
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Title: Diabetes care Volume: 34 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-26 Completed Date: 2012-05-11 Revised Date: 2012-05-21 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1913-8 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anthropometry Diabetes Mellitus, Type 2 / epidemiology* Diet, Mediterranean* Female Humans Life Style Male Middle Aged Prospective Studies Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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