| Mediterranean Diet Supplemented With Coenzyme Q10 Modifies the Expression of Proinflammatory and Endoplasmic Reticulum Stress-Related Genes in Elderly Men and Women. | |
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MedLine Citation:
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PMID: 22016358 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have investigated whether the quality of dietary fat and supplementation with coenzyme Q(10) (CoQ) modifies expression of genes related with inflammatory response and endoplasmic reticulum stress in elderly persons. Twenty participants received three diets for 4 weeks each: Mediterranean diet + CoQ (Med + CoQ), Mediterranean diet (Med), and saturated fatty acid-rich diet (SFA). After 12-hour fast, volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet. Med + CoQ diet produced a lower postprandial decrease p65 and IKK-b gene expression compared with the other diets. Our results support the anti-inflammatory effect of Med diet and that exogenous CoQ supplementation in synergy with a Med diet modulates the inflammatory response and endoplasmic reticulum stress. |
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Authors:
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Elena M Yubero-Serrano; Lorena Gonzalez-Guardia; Oriol Rangel-Zuñiga; Javier Delgado-Lista; Francisco M Gutierrez-Mariscal; Pablo Perez-Martinez; Nieves Delgado-Casado; Cristina Cruz-Teno; Francisco J Tinahones; Jose M Villalba; Francisco Perez-Jimenez; Jose Lopez-Miranda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: - ISSN: 1758-535X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Lipids and Atherosclerosis Unit, Reina Sofia University Hospital, Avda. Menendez Pidal, s/n. 14004 Córdoba, Spain. jlopezmir@uco.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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