| Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 22778122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was designed to evaluate potential preventive effects of meditation or exercise on incidence, duration, and severity of acute respiratory infection (ARI) illness. METHODS: Community-recruited adults aged 50 years and older were randomized to 1 of 3 study groups: 8-week training in mindfulness meditation, matched 8-week training in moderate-intensity sustained exercise, or observational control. The primary outcome was area-under-the-curve global illness severity during a single cold and influenza season, using the Wisconsin Upper Respiratory Symptom Survey (WURSS-24) to assess severity. Health care visits and days of missed work were counted. Nasal wash collected during ARI illness was assayed for neutrophils, interleukin-8, and viral nucleic acid. RESULTS: Of 154 adults randomized into the study, 149 completed the trial (82% female, 94% white, mean age 59.3 ± 6.6 years). There were 27 ARI episodes and 257 days of ARI illness in the meditation group (n = 51), 26 episodes and 241 illness days in the exercise group (n = 47), and 40 episodes and 453 days in the control group (n = 51). Mean global severity was 144 for meditation, 248 for exercise, and 358 for control. Compared with control, global severity was significantly lower for meditation (P = .004). Both global severity and total days of illness (duration) trended toward being lower for the exercise group (P=.16 and P=.032, respectively), as did illness duration for the meditation group (P=.034). Adjusting for covariates using zero-inflated multivariate regression models gave similar results. There were 67 ARI-related days of-work missed in the control group, 32 in the exercise group (P = .041), and 16 in the meditation group (P <.001). Health care visits did not differ significantly. Viruses were identified in 54% of samples from meditation, 42% from exercise, and 54% from control groups. Neutrophil count and interleukin-8 levels were similar among intervention groups. CONCLUSIONS: Training in meditation or exercise may be effective in reducing ARI illness burden. |
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Authors:
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Bruce Barrett; Mary S Hayney; Daniel Muller; David Rakel; Ann Ward; Chidi N Obasi; Roger Brown; Zhengjun Zhang; Aleksandra Zgierska; James Gern; Rebecca West; Tola Ewers; Shari Barlow; Michele Gassman; Christopher L Coe |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Annals of family medicine Volume: 10 ISSN: 1544-1717 ISO Abbreviation: Ann Fam Med Publication Date: 2012 Jul-Aug |
Date Detail:
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Created Date: 2012-07-10 Completed Date: 2012-11-16 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 101167762 Medline TA: Ann Fam Med Country: United States |
Other Details:
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Languages: eng Pagination: 337-46 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, University of Wisconsin - Madison, 1100 Delaplaine Ct, Madison, WI 53715, USA. bruce.barrett@fammed.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adaptation, Psychological Common Cold Confidence Intervals Exercise Therapy / methods*, psychology Female Health Status Indicators Humans Influenza, Human / prevention & control, psychology Male Meditation / methods*, psychology Middle Aged Psychometrics Respiratory Tract Infections / prevention & control*, psychology, therapy Self Report Severity of Illness Index Stress, Psychological |
| Grant Support | |
ID/Acronym/Agency:
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1R01AT004313/AT/NCCAM NIH HHS; K23 AA017508/AA/NIAAA NIH HHS; K23 AT00051/AT/NCCAM NIH HHS; UL1 TR000427/TR/NCATS NIH HHS; UL1RR025011/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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