Document Detail

Medicine at high altitude.
MedLine Citation:
PMID:  17228562     Owner:  NLM     Status:  MEDLINE    
Medicine at high altitude provides important insights into the acute and chronic effects of hypoxia. Acute mountain sickness (AMS) is a common syndrome occurring after acute ascent to over 2,500 m and is caused by increased capillary permeability. A number of factors have been identified that increase the risk of AMS, in particular exercise. Avoiding rapid ascent, undue exercise and the use of acetazolamide are useful preventative measures but severe symptoms may require oxygen, dexamethasone and descent. Acute mountain sickness is usually self-limiting but may progress into the serious syndromes of pulmonary and cerebral oedema. Acclimatisation and adaptation are important for workers and residents at high altitude and the improvement seen in maximum exercise has been incorporated into some training schedules for endurance athletes. Chronic and subacute high-altitude diseases largely result from polycythemia and pulmonary hypertension.
Alex D Wright;
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical medicine (London, England)     Volume:  6     ISSN:  1470-2118     ISO Abbreviation:  Clin Med     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2007-01-18     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092853     Medline TA:  Clin Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  604-8     Citation Subset:  IM    
University of Birmingham.
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MeSH Terms
Acute Disease
Altitude Sickness / physiopathology,  prevention & control*
Brain Edema / etiology
Chronic Disease
Pulmonary Edema / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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