| Medicinal therapy of metastasized neuroendocrine tumors of the gastroenteropancreatic system. | |
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MedLine Citation:
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PMID: 22294240 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Neuroendocrine neoplasms of the gastroenteropancreatic system are classified according to the WHO classification system 2010 into neuroendocrine tumors (NET) and neuroendocrine carcinomas (NEC). The proliferation index Ki-67 and the grading of NETs is essential for the prognosis and therapy plan. Also NET tumor biology and therapeutic options may differ depending on the primary NET tumor location. Palliative therapy of inoperable NETs involves local ablative methods in cases of primary liver metastasis, peptide receptor radionuclide therapy (PRRT) in NETs expressing somatostatin receptors and different options for medicinal therapy. This manuscript reviews the current role of biotherapy with somatostatin analogues and interferon-alpha for symptom and tumor control. In addition conventional chemotherapy regimens and novel molecular targeted therapeutic options, such as sunitinib or everolimus in NET of the pancreas are reviewed. Possible therapeutic algorithms are discussed. |
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Authors:
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C J Auernhammer; C Spitzweg; V Heinemann; B Göke |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: Der Internist Volume: - ISSN: 1432-1289 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0264620 Medline TA: Internist (Berl) Country: - |
Other Details:
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Languages: GER Pagination: - Citation Subset: - |
Affiliation:
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Medizinische Klinik II, Campus Großhadern, Klinikum der Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Deutschland, christoph.auernhammer@med.uni-muenchen.de. |
Vernacular Title:
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Medikamentöse Therapie bei metastasierten neuroendokrinen Tumoren des gastroenteropankreatischen Systems. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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