Document Detail

Medicinal significance of benzothiazole scaffold: an insight view.
MedLine Citation:
PMID:  23030043     Owner:  NLM     Status:  Publisher    
Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important class of compounds possessing a wide spectrum of biological activities. The myriad spectrum of medicinal properties associated with benzothiazole related drugs has encouraged the medicinal chemists to synthesize a large number of novel therapeutic agents. Several analogues containing benzothiazole ring system exhibit significant antitumour, antimicrobial, antidiabetic, anti-inflammatory, anticonvulsant, antiviral, antioxidant, antitubercular, antimalarial, antiasthmatic, anthelmintic, photosensitizing, diuretic, analgesic and other activities. This article is an attempt to present the research work reported in recent scientific literature on different pharmacological activities of benzothiazole compounds.
Prabodh Chander Sharma; Alka Sinhmar; Archana Sharma; Harish Rajak; Dharam Pal Pathak
Related Documents :
24780593 - Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1h-pyrazol-4-yl)-1,3,4-oxadiazol...
23240913 - Capturing labile sulfenamide and sulfinamide serum albumin adducts of carcinogenic aryl...
9400743 - Interspecies comparison of rat and hamster alveolar macrophage antioxidative and oxidat...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  -     ISSN:  1475-6374     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Pharmaceutical Sciences, Kurukshetra University , Kurukshetra , India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structural basis for isoform-selective inhibition in nitric oxide synthase.
Next Document:  Molecular Dynamics Simulations to Examine Structure, Energetics and Evaporation/Condensation Dynamic...