Document Detail


Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol absorption-inhibitory activity from a food garnish "Tonburi", the fruit of Japanese Kochia scoparia (L.) Schrad.: structures of scoparianosides A, B, and C.
MedLine Citation:
PMID:  9301029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The methanolic extract of a food garnish "Tonburi", the fruit of Japanese kochia scoparia (L.) Schrad. (Chenopodiaceae), was found to inhibit the increase in serum glucose-loaded rats. Through bioassay-guided separation, momordin Ic and its 2'-O-beta-D-glucopyranoside were isolated as the active principles from this medicinal foodstuff together with three new saponins named scoparianosides A, B, and C. The structures of scoparianosides A, B, and C were elucidated on the basis of chemical and physicochemical evidence as 3 beta, 22 alpha-dihydroxyolean-12en-28-oic acid (22 alpha-hydroxyoleanolic acid), 3-O-beta-D-xylopyranosyl (1 --> 3)-beta-D-glucopyranosiduronic acid, 3 beta-hydroxyolean -18-en-28-oic acid (morolic acid), 3-O-beta-D-xylopyranosyl(1 --> 3)-beta-D -glucopyranosiduronic acid, and 3 beta-hydroxyolean-13(18)-en-28-oic acid, 3-O-beta-D-xylopyranoxyl(1 --> 3) -beta-D-glucopyranosiduronic acid. Momordin Ic and its 2'-O-beta-D-glucopyranoside, both of which are the principal saponin constituents of this medicinal foodstuffs, were found to potently inhibit glucose and ethanol absorption in rats.
Authors:
M Yoshikawa; H Shimada; T Morikawa; S Yoshizumi; N Matsumura; T Murakami; H Matsuda; K Hori; J Yamahara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  45     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-30     Completed Date:  1997-10-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1300-5     Citation Subset:  IM    
Affiliation:
Kyoto Pharmaceutical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System Depressants / blood,  pharmacokinetics*
Chemistry, Physical
Chenopodiaceae / chemistry
Ethanol / blood,  pharmacokinetics*
Fruit / chemistry*
Glucose / pharmacokinetics*
Hydrolysis
Hypoglycemic Agents / isolation & purification*,  pharmacology
Japan
Magnetic Resonance Spectroscopy
Male
Oleanolic Acid* / analogs & derivatives*
Physicochemical Phenomena
Plants, Medicinal / chemistry*
Rats
Rats, Wistar
Saponins / isolation & purification*,  pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Hypoglycemic Agents; 0/Saponins; 0/scoparianoside A; 0/scoparianoside B; 0/scoparianoside C; 50-99-7/Glucose; 508-02-1/Oleanolic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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